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30 Tactics Used by the Medical Profession to Hoodwink the Public

Immunization Ploys
Are Parents Being Manipulated?

30 Tactics Used by the Medical Profession
to Hoodwink the Public

http://thinktwice.com/ploys.htm

       Medical health authorities, including doctors, nurses, and other members of the allopathic fraternity, employ a number of strategies designed to elicit parental submission to vaccine guidelines. Currently, parents are expected to grant authorities permission to toxify their children’s pure and sacred little bodies with more than 30 blends of rare germs, bacteria, and other foul substances — all before they enter school!

To adequately assess the relevance of vaccine-related news, or the perils of vaccine-related situations you may find yourself in — and to increase your knowledge about how to protect your loved ones — several of the more common vaccine-related schemes you’re likely to encounter are included in the following section, along with samples of each.

1. Calling the Shots “Immunizations.” Numerous studies indicate that vaccines cannot be relied upon to boost the immune system and protect an individual from contracting the disease the vaccines were designed to offset. For example, the Minnesota Department of Health reported 769 cases of mumps in school children. But 632 of these cases (82 percent) occurred in children who were previously vaccinated against this disease.(119) The Centers for Disease Control and Prevention (CDC) reported that 89 percent of all school-age children who recently contracted measles had been vaccinated against the disease.(120-122) And the New England Journal of Medicine published a study revealing that the pertussis vaccine “failed to give…protection against the disease.” In fact, more than 80 percent of cases in a recent epidemic occurred in children who had received regular doses of the shot.(123,124)

According to Dr. Sandra Huffman, head of Nurture: The Center to Prevent Childhood Malnutrition, “Increasing Americans’ breastfeeding rate would prevent more childhood diseases — and deaths — than [vaccination programs endorsed by the government].”(125) A distinction must therefore be made: breastfed babies are immunized;(126-128) children who are injected with germs and other toxic substances are vaccinated.

Calling the shots “preventive medicine” is deceptive as well. According to Dr. Kenneth Cooper, pioneering author of Aerobics, “My concept of preventive medicine is trying to prevent the things that kill us. Infectious disease is way down the list.”(129) (Dr. Cooper was ostracized from the medical community for promoting exercise to improve health!)

2. Rationalization and Denial. Medical personnel find it difficult to confront the vaccine issue head-on. It is much easier to falsely justify the use of vaccines or simply reject the idea that they may be unsafe and ineffective. Some doctors become so agitated when the topic is raised, they refuse to even discuss it. Doctors who are willing to exchange ideas and concerns regarding the safety and efficacy of vaccines often rely upon rationalization and denial.

The rationalization and denial ploy can be blatant or veiled. Blatant rationalization is easier to spot. For example, in a recently published pediatric legal paper, a Canadian neurologist candidly writes, “In this article [on vaccine-induced brain injury], I will…offer some suggestions for pediatricians to rationalize this emotional controversy.” He also plainly states, “A vigorous effort is required to dispel the myth of DTP-induced brain damage.”(130) He makes his recommendation in spite of the horrendous amount of literature in the medical journals indicating a causal relationship between this vaccine and severe mental impairment.(131)

The veiled Rationalization and Denial ploy is harder to detect. At first it appears logical and sound. But it merely represents a more intricate attempt at suppressing and confounding the truth. For example, according to some researchers, the DPT vaccine does not cause seizures; instead, “fever from the DTP vaccine may trigger one of these seizures.”(132) Or, according to an experienced vaccine policymaker, Ed Mortimer, M.D., “These kids already had underlying problems and DTP was the first fever-producing insult that occurred to the child.”(133) Again, it wasn’t the vaccine that caused the brain damage; it was the fever from the vaccine.

More examples of the rationalization and denial ploy:

When the incidence of a disease is low, authorities claim high vaccination rates are responsible. When outbreaks occur, we are told not enough people received the shots. For example, prior to a recent measles outbreak in a Hobbs, New Mexico, school district, authorities boasted a 98 percent vaccination rate. Then, when 76 cases of the disease broke out, researchers claimed that “vaccine failure was associated with immunizations that could not be documented in the provider’s records.”(134)

Although the Food and Drug Administration was legally bound to establish and oversee the Vaccine Adverse Event Reporting System (VAERS), and even though every year about 12,000 reports of adverse reactions to vaccines are made to the FDA,(135) authorities refuse to follow up on these cases because “the agency could not possibly investigate each report,” and besides, “a cause and effect relationship is not presumed.”(136)

By November 10, 1999, the Vaccine Injury Compensation System had already paid out more than $1 billion to settle claims of vaccine-induced damage or death.(137) However, because vaccine manufacturers and the federal government are not required to admit responsibility, even when a claim is paid, they are able to assert that “the settlement of a claim does not necessarily establish liability.”(138)

3. Double Talk and Creative Logic. Medical advisers were using this ploy as far back as 1806. In that year Edward Jenner, the dubious “father of modern vaccinations,” was under examination by a College of Physicians committee. Numerous members of the English population who had recently been vaccinated with Jenner’s concoction, and who were therefore considered immune to smallpox, had caught the disease. Many were afflicted with painful skin eruptions and died. When the commonly relied upon denial ploy was no longer effective, it was revealed that “spurious,” or phony, cowpox was the cause. As the number of vaccinated people afflicted with the disease grew, so, too, did public fear. How, Jenner was asked, could spurious cowpox be identified and avoided? Spurious cowpox, he explained, wasn’t meant to describe irregularities on the part of the cow, but rather certain quirks in the action of cowpox on the part of the vaccinated. In other words, when the vaccinated recovered from the ordeal, and did not contract smallpox, the cowpox was genuine; otherwise it was spurious.(139)

Current uses of the double talk ploy may be found at almost any forum or seminar where vaccine policymakers congregate. For example, at a recent FDA workshop officials indicated they were justified in administering new and unproven vaccines by claiming it is unethical to withhold them!(140)

Here is another example of the “unethical” argument: A recent study found that the AIDS virus directly causes cancer. You’d think this would stifle the researchers’ goal of creating an AIDS vaccine. In fact, Gerald Myers, director of the HIV Sequence Database Analysis Project at Los Alamos National Laboratory, warrants that a live vaccine would carry a risk of causing cancer — both in the vaccinated person and in their offspring. Nevertheless, he claims that “the risk might be worth it” to prevent the spread of AIDS. “It could be unethical not to try it.”(141)

A common use of the double talk and creative logic ploy may be found whenever health officials make the outrageous claim that unvaccinated children are a threat to the rest of society. This argument indicates how little faith authorities place in their own vaccines. If the vaccines were truly effective, only the unvaccinated would be at risk. This argument also overlooks the potential for vaccinated individuals to spread the virus to unvaccinated populations. For example, in separate scientific studies, the new rubella vaccine introduced in 1979 was found to be a cause of Chronic Fatigue Syndrome, an immunological disorder first reported in the United States in 1982. Given to children, the vaccine was shown to linger in their systems for years and the vaccine virus can be passed on to adults through casual contact.(142-144)

In an attempt to conceal vaccine failures, medical authorities will often resort to the double talk ploy, sometimes in conjunction with the scare tactics ruse. In spite of their enterprising babble, however, they can’t always hoodwink the public. For example, the international Medical Observer states that “a new strain of measles resistant to vaccine” has been discovered. This is immediately contradicted by the statement: “Those who have been lax about vaccination will be unprotected.” Although the implication is that everyone should get vaccinated, a vaccine is obviously useless if a new strain of measles is resistant to it!(145)

More examples of the double talk ploy:

Scientists seeking human volunteers to test a new experimental AIDS vaccine try to assuage fear and mistrust by claiming there is “no evidence” it will cause AIDS. How could there be evidence? It is new and experimental and hasn’t been tested yet! And, of course, there is “no evidence” that it won’t cause AIDS.(146)

In an attempt to convince the public that vaccines offer the best of all worlds, medical researchers, and the journalists who quote them, often get tangled in their own webs of deception. For example, in a recently published pro-vaccine article, the author claims that unvaccinated children are susceptible to infection. He then contradicts himself by claiming that vaccinated children “insulate” or protect, the unvaccinated. The illogical implication is that when unvaccinated children contract an infectious disease it is because they are unvaccinated. However, if they remain free from disease, it is because the vaccinated are providing them with immunity.(147)

Every so often the double talk employed by authorities is so transparent it’s bewildering that so few people question its validity. In a recent promotional blitz, flu vaccine manufacturers and public health officials made the claim that the new and improved flu vaccine “is prepared from inactivated flu virus [Translation: “dead” flu virus — see Euphemisms addressed below] and cannot cause the disease.” (A rare admission that earlier versions did cause the disease.) In the same paragraph they warn that “some individuals might develop a mild fever and feeling of malaise” for a few days after receiving the shot.(148) (Sounds like the flu to me!)

Other times the double talk employed by vaccine researchers is remarkably elaborate. Although it is a simple matter to determine the efficacy of a vaccine — give it to people who want it, withhold it from those who don’t, and tally the incidence of disease — some scientists have other ideas. One writes: “Under heterogeneity of vaccine effect, a general expression for a summary vaccine efficacy parameter is a function of the vaccine efficacy in the different vaccinated strata weighted by the fraction of the vaccinated subpopulations in each stratum. Interpretation and estimability of the summary vaccine efficacy parameter depends on whether the strata are identifiable, and whether the heterogeneity is host- or vaccine-related.” To support this garrulous babble, a full-page mathematical model is provided.(149)

A final look at the double talk and creative logic ploy yields the following revelations: children who keep to “appropriate” vaccine schedules are “protected,” unless they haven’t yet received the full battery of shots and contract the affliction — in which case they are evidently “still susceptible to the disease.”(150) In such instances the vaccine does not fail, or worse, cause the disease; these become “non-preventable” cases!(151)

4. The “I Forgot to Mention” ploy is a common tactic used by health and medical authorities with an interest in omitting vital information. For example, a spokesman for the Ohio Department of Health supplied the Dayton Daily News with these statistics: 2,720 cases of measles were reported in Ohio during a recent year. This figure was used in conjunction with the godfather ploy (an offer hard to refuse) when the following threat was made as well: “Get shots or forget 7th grade.” What the official failed to mention was that more than 72 percent of these cases occurred in vaccinated people.(152) This figure is comparable to other outbreaks around the country, where a majority of measles cases often occur in vaccinated children, “sometimes in schools with vaccination levels of greater than 98 percent.”(153,154)

A concerned individual recounts her personal experience with the measles vaccine and the “I forgot to mention” ploy: “Fort Lewis College had a measles epidemic and the school closed down for a short time. The following year, I returned as a postgraduate for a teacher’s certificate and was denied reentry until I submitted to a measles vaccine — even though I had been fully vaccinated as a child. This fall I reentered Fort Lewis College, and they wanted me to get another measles shot! They told me the one I had already taken ‘didn’t work.’ I refused the shot and told them I was refusing all other shots as well. They replied, ‘Okay, just sign this waiver.’ No one ever tells you that the shots may be declined by signing a personal waiver.”(155)

Another example of the “I forgot to mention” ploy may be found in official evaluations of Reye’s Syndrome, an often fatal disease of the brain and liver. According to Dr. Robert Mendelsohn, the CDC is “quick to suggest a relationship between [this childhood disease] and certain flu outbreaks,” but they make no mention of “an association between this disease and the flu vaccine itself.”(156)

5. Gimmicks. Devising strategies to boost vaccination rates is a prime preoccupation of vaccine policymakers. Without doubt, the gimmick ploy is a proven winner. In fact, the AMA recently admitted that “adult vaccines need a gimmick.”(157) CDC physicians recommend catchy slogans, like “Vaccines are not just kid stuff.”(158) Shari Lewis and her puppet, Lamb Chop, were seen delivering pro-vaccination messages to the public on TV.(159) Even Bill Clinton was seen in print ads imploring parents to be sure their children receive “All their shots while they’re tots.”(160)

6. Bribes. Within the same family of wily maneuvers, one may find the bribe ploy. For example, in England the National Health Service pays a “bonus” to doctors with vaccination rates above specified percentages.(161) Here in the United States, former president Jimmy Carter was seen on TV offering free Michael Jackson concert tickets to parents who agreed to vaccinate their children.(162) In Saginaw County, Michigan, children were promised “a free order of french fries” if they were one of the first thousand people to receive their shots.(163) And in Taos, New Mexico, “all students who return consent forms and receive vaccinations will be entered in raffles for great prizes!”(164)

7. Skewed Statistics. Researchers are trying to develop a new vaccine to combat respiratory syncytial virus (RSV) — even though Dr. Bill Gary of the Centers for Disease Control and Prevention (CDC) admits that “an RSV vaccine was developed 10 to 15 years ago, but was unsuccessful and made many people ill.” To foster interest in this obscure project, and to improve the illusion that we need the vaccine, a recent report released by the CDC indicates that “about half” of the 69 labs that track diseases for the agency reported a 16 percent increase in RSV cases.(165) Stating “about half” is deceptively vague, and choosing not to list the percent increase or decrease of RSV cases in the other “about half” of the 69 labs is manipulative and dishonest.

Another good example of the skewed statistics ploy came from the Clinton administration. Goaded by the medical community, federal authorities announced their dubious goal to vaccinate all U.S. children. To accomplish this feat, Clinton sought $300 million from Congress. To bolster his case he made the bogus claim that “we can prevent the worst infectious diseases of children with vaccines and save $10 for every $1 invested.”(166) But he failed to supply facts and figures to support his claim. Perhaps this was because the administration chose instead to invoke the “I forgot to mention” ploy, conveniently neglecting to factor in the millions of dollars the government had already spent compensating families of children damaged or killed by the vaccines.(167)

A further example of the skewed statistics ploy:

The use of control subjects (individuals utilized as a standard of comparison for verifying the results of an experiment) is an established procedure in most fields of scientific inquiry. Not so within the vaccine research community. New experimental vaccines that are tested on a group of people are rarely matched against an equal number of untested people. Indeed, after a new AIDS vaccine was tested on hundreds of people, some of the volunteers were found to be infected with HIV. However, because the number of control subjects was suspiciously small (38 people) — and therefore worthless — the National Institutes of Health (NIH) was able to claim “there is no statistical basis for concluding that the vaccine has contributed to an increased vulnerability to infection.”(168)

8. The Fraud ploy has proven to be an early and consistent success. In 1956, soon after the Salk polio vaccine was introduced, officials decided to determine how safe and effective it really was. The results of this study — the now infamous Francis Field Trials — would help determine the feasibility of continuing to vaccinate millions of young children. What they discovered would have stopped most ethical people from continuing: large numbers of children were contracting polio after receiving the vaccine. Clearly, the vaccine was either unsafe (it was causing the disease it was meant to prevent) or ineffective (it failed to protect). Instead of removing the vaccine from the market, however, officials decided to exclude from the statistics all cases of polio that occurred within 30 days after vaccination on the pretext that such cases were “pre-existing.”(169,170)

The NIH, an influential branch of the vaccine oligarchy, was recently placed under investigation for interfering with charges of scientific fraud within its own ranks. According to a New York Times report, Walter W. Stewart and Dr. Ned Feder, scientific fraud investigators for the NIH, were summarily dismissed from their duties following the release of a report critical of other NIH scientists. Without warning their offices were closed and sealed, along with all the files of current investigations. The two scientists were then transferred to jobs unrelated to their work of previous years. This incident reveals how studies and reports critical of official dogma may be suppressed, and highlights “the continuing ethical battles over how government and universities should monitor scientists.”(171)

9. Fortune-telling. When medical and health authorities are at a loss to explain the cause of injury and death that occurs soon after a childhood shot, and denial is insufficient, they may resort to the fortune-telling ploy. In fact, the FDA’s official position is that “the ‘event’ [Translation: adverse reaction to a vaccine — see the Euphemism ploy] may have been related to an underlying disease or condition…or may have occurred by chance at the same time the vaccine was administered.” In other words, the child was destined to be damaged or die at the time of the shot anyway.(172)

The past director of the Ohio Department of Health, and other vaccine authorities, label vaccine-induced injury or death as “only temporal.: Once again, this translates to mean the damage was coincidental; it would have occurred anyway.(173)

More examples of the fortune-telling ploy:

“Bad Flu Season Forecast” blared the headlines. “A severe flu season is at hand; get flu shots right away.”(174) Who are these doomsday prophets, and where do they get their psychic news?

According to the U.S. government’s Morbidity and Mortality Weekly Report (MMWR), the efficacy of a flu vaccine depends upon whether the government has correctly “predicted” [Translation: guessed] which viruses should be placed in that year’s vaccine. There has to be a “good match” between the flu virus actually present in the community at the end of the year and the vaccine that was produced several months earlier.(175)

10. “Pardon Me.” Medical institutions wary of vaccine reactions often protect their members by enforcing the “pardon me” rule, exempting doctors from their own regulations. For example, in Evanston, Illinois, a 46-year-old social worker was fired from her job when she refused to take a rubella shot. Hospital policy requires all employees —except physicians — to be vaccinated against rubella. Doctors are not considered “employees.”(176)

A study published in the Journal of the American Medical Association reports that obstetrician-gynecologists are the least likely of all doctors to submit to the rubella vaccine. Fewer than 10 percent are inoculated, and blood tests indicate they are susceptible to rubella. The researchers conclude that a “fear of unforeseen vaccine reactions” lead these specialists to invoke their self-exempting “pardon me” rule.(177)

Some doctors refuse to vaccinate their own children as well. According to Dr. Jerome Murphy, former head of Pediatric Neurology at Milwaukee Children’s Hospital, “There is just overwhelming data that there’s an association [between the pertussis vaccine and seizures]. I know it has influenced many pediatric neurologists not to have their own children immunized with pertussis.”(178)

The FDA recently lost an important legal battle when they permitted the live virus polio vaccine, manufactured by Lederle Labs, to be released to the public even though it did not meet existing safety standards. As a result, several people were severely damaged. After losing the U.S. Supreme Court case, the FDA immediately implemented the “pardon me” ploy, and rewrote its safety procedures so that previously unacceptable safety measures would be allowable. Consequently, Lederle can continue to produce and the FDA can continue to sanction the same kind of polio vaccine that caused injuries in the first place.(179)

11. Delusions of Grandeur. Doctors, medical scientists, allopathic policymakers, and vaccine manufacturers, are prone to experience delusions of grandeur. This occurs whenever they take credit for a drop in nearly every communicable disease. But a greater than 95 percent decline in the incidence and severity of many of these diseases already occurred before the introduction of the vaccines. Such conceit also disregards the many diseases — like scarlet fever and the plague — that declined on their own, even though vaccines were not developed against them.(180)

Health officials claim high vaccination rates are required to disrupt the spread of a disease and eliminate its occurrence. For example, they take full credit — delusions of grandeur — for the current low incidence of polio in the United States. However, in many European countries that refused to mandate polio vaccines a fraction of the people were vaccinated, and polio disappeared.181 To explain this enigma, officials rely upon the double talk and creative logic ploy: evidently enough people were vaccinated “to interrupt the virus’s normal lines of transmission through the population.” Yet, countries like Finland used the killed-virus vaccine, which officials do not credit with the ability to confer immunity upon the unvaccinated!(182)

More recently, Finland has claimed to have “eradicated” measles, mumps, and rubella — even though only 30 percent of the people were vaccinated. Also, although researchers claim these diseases were “eradicated,” they note that there are about “ten cases of each disease a year, most of them ‘probably imported’ [from another country].”(183)

Vaccine policymakers promised that by 1982 measles would be eradicated from the Earth�delusions of grandeur.184 Today, in the 1990s, it has returned with a vengeance. The death rate for measles is more than 20 times higher than before the vaccine was in widespread use.(185)

Medical policymakers are unrelenting in their efforts to play God. After realizing “the number of visits to a healthcare provider [for vaccines] is an impediment” to receiving the entire battery of shots, they proposed the development of a single vaccine to provide “lifelong immunization” against many common childhood diseases. They call this single shot a “supervaccine” or “magic bullet” and have lobbied Congress for funds to continue research along these lines.(186) When we consider the medical community’s inability to provide lifelong immunity against a single disease, their dismal success rate with current multiple vaccines (DPT and MMR), and the number of vaccine-related injury and death claims clogging the courts, this latest “mad science” venture clearly demonstrates their wicked propensity toward delusions of grandeur.

12. Surprise Attack. Parents often report they are harassed by medical personnel wishing to vaccinate their children even when they visit their medical health care provider for other reasons. In fact, some doctors appear to be so obsessed with the vaccination status of their clients that they disregard the stated purpose of the visit. Therefore, anticipate the surprise attack.

The surprise attack is actually taught to members of the medical fraternity, as noted in the Journal of the American Medical Association: “Each encounter with a health care provider, including an emergency department visit or hospitalization, is an opportunity to screen immunization status and, if indicated, administer needed vaccines. Before discharge from the hospital, children should receive immunizations for which they are eligible. In addition, children accompanying parents or siblings who are seeking any service should also be screened and, when indicated, given needed vaccines.”(187)

The consequences of being unprepared for the surprise attack can be severe indeed. The Jonathan story published elsewhere on this site illustrates one parent’s reaction to being ambushed by the medical profession.

Another concerned mother describes her surprise attack in these words:

“My husband and I chose a midwife and had a homebirth, which was wonderful. The midwife insisted that I take our daughter to a local pediatrician for a newborn exam…. The reason I’m telling you this is because we were treated like trash. I was told that a homebirth is an automatic ‘red flag.’ The doctor reported us to Social Services, and we were subjected to a painful interrogation. I was [also] interrogated as to my beliefs about immunizations. My daughter was only two weeks old…and yet they wanted to inject her with multiple vaccines.

“How can I find a doctor for my daughter? I do not want to repeat this horrible experience…for fear Social Services will again be sent to investigate us because we don’t take our daughter to doctors for regular ‘well-baby’ checkups, which is really a ploy to force vaccines on innocent babies and unsuspecting parents.”(188)

13. Intimidation and Coercion. Doctors often claim vaccines are mandatory. Many threaten to withhold treatment, or they frighten parents when they reject the shots. As one mother puts it: “The pediatrician I have refused to service me because I am not willing to follow medical ‘rules.’ Another M.D. agreed to work with me, but only after I listened to him warn me [in very explicit terms, about all the dangers that could happen to my child.]”(189)

Another mother writes: “I am a concerned parent who has not vaccinated my 13 month old. I am met by my baby doctor in a critical and almost attacking nature. There seems to be no room in his mind-set for a choice on this issue.”(190)

Putting this in clearer perspective, another mother writes: “I am an Australian citizen [living in the United States]. I never realized what an issue [vaccinations are] in this country until I had my own children, and how much pressure the medical world puts on you, and above all else, how much clout the schools have. I really don’t know of any other country that makes this into such a difficult decision, and so one-sided in regard to information. Where I’m from, you either do, or you don’t, immunize. The question is asked, the decision made, and that’s it forever, unless you change your mind! Incidentally, a large majority [of parents in Australia] do not immunize [their children], and we don’t have a higher incidence [of disease] than in the U.S.”(191)

Note: The United States has one of the worst infant mortality rates among developed countries. In fact, the rate at which babies die in the first year of life has consistently increased since the 1950s when mass immunization campaigns were initiated. Today, infant mortality rates in some U.S. cities match those in developing countries.(192)

Public school officials — the unwitting henchmen for the medical profession — often warn parents their children will not be able to enter school without complying with vaccine mandates. Each state, however, offers one or more exemptions to the shots. In spite of these exemptions, one mother was told by authorities that she would need to write a letter explaining why her son was not vaccinated, and that she would accept full responsibility for any epidemics that occurred while her child was enrolled at the school!(193)

A concerned father tells this story: “I applied for religious exemption for my son at his public school in Totowa, New Jersey. The school nurse reported the exemption to the Board of Health. The New Jersey State Immunization Supervisor then sent a letter to the school principal. In it he stated that my letter of exemption was ‘not good enough,’ and that my son is not to be admitted into the school building at all. The school principal wrote me a letter confirming that my son would not be permitted to enter school, and threatened that `I had better begin immunizing’ my son. I must meet the August deadline to register my son for school, but they won’t even let him in the building. Time is running out, and my son’s education is being denied.”(194)

Note: This story is often told by parents throughout the nation. Evidently, state laws are immaterial to authorities intent upon using the intimidation and coercion ploy to deny parents their legal rights. For example, a clause in the New Jersey State Sanitary Code, Chapter 26:1A-9.1, allows for “exemption for pupils from mandatory immunization if the parent or guardian objects thereto in a written statement signed by the parent or guardian upon the ground that the proposed immunization interferes with the free exercise of the pupil’s religious rights.”

An apprehensive California mother reports that when her child was rushed to the hospital emergency room for a minor mishap, medical personnel were more interested in the child’s vaccination status than in the nature of her injury [the surprise attack]. Upon learning the child was not “up-to-date” on her shots, they refused to release the child to her mother until she gave her permission for the shots to be administered. When she refused, these doctors reported her to Social Services, claiming she was “abusing her child.” Soon thereafter the State Attorney General joined in the case and sought to prosecute the mother —even though the vaccine laws in her state permit parents the option to refuse vaccines based on personal convictions against them!(195)

Many parents report that doctors and nurses are intimidating them into vaccinating their newborns immediately after birth. One mother reports: “The very first time I heard about the hepatitis B vaccine was at the hospital after giving birth to my second child. They told me all babies must receive this vaccine before they can be released from the hospital. Needless to say, I refused it, although they persisted in badgering me. Later, when I took my baby to the pediatrician for her two-week checkup, he tried to frighten me into giving her the shot. He said hepatitis is very contagious and my child could easily catch it from other kids or infected adults. When I told him that I didn’t feel right about giving the vaccine to my infant, he informed me that I would need to find another doctor because he would not treat my baby.”(196)

On November 20, 1993, a nationally syndicated prime-time TV news magazine, The Crusaders, aired a gutsy show on the dangers of the DPT vaccine. Parents of vaccine-damaged children were interviewed, and rare, emotionally wrenching footage of their severely disabled children was shown. While most of the American medical community denies a link between the shots and brain damage or death, listeners heard vaccine expert Dr. Michael Pakickero warn parents that some batches of the DPT vaccine are more toxic than others. And, Dr. John Menkis, the former head of pediatrics and neurology at UCLA, candidly acknowledged, “You will have permanent, irreversible brain damage, which was not present before [DPT] vaccination.” Meanwhile, Michael Settonni, the show’s premier research journalist, estimated from government sources that “at least two children are reportedly killed or injured by the vaccine every day.”(197)

A few days after this show aired, Mr. John Butte, executive producer of The Crusaders, received a scathing letter from Thomas Balbier, Jr., Director of the National Vaccine Injury Compensation Program (VICP), demanding a retraction. He asserted that the number of current vaccine injury and death claims filed by parents during the past few years represent claims of damage “for virtually the entire 20th century.” He also blasted the show for directing listeners to the National Vaccine Information Center (NVIC) — a nonprofit organization dedicated to improving vaccine safety and supporting a parent’s right to choose for or against vaccines. He claimed that NVIC is “not sanctioned” by the federal government, and therefore is “not the official spokesperson” for information on vaccine safety. He also made what appeared to be a veiled threat by noting that copies of his letter were being sent to the U.S. Department of Justice and the Federal Communications Commission.(198)

Note: On January 8, 1994, The Crusaders aired a retraction by quoting the medical industry’s most cherished — and fraudulent — data on the DPT vaccine: a controversial study conducted in Great Britain during the 1950s. Even though 42 of the babies in the study had convulsions within 28 days of receiving the shots, 80 percent of the babies were 14 months of age or older, and the tests were designed to test the efficacy (not safety) of the vaccine, U.S. health authorities still use these results as evidence that the vaccine is safe to give to babies as young as six weeks of age.199 Obviously, the intimidation and coercion ploy was, once again, a wicked success.

On March 19, 1992, Rolling Stone magazine published a remarkable story documenting potential correlations between the first polio vaccines and AIDS. Many independent researchers considered the expos� forthright and extraordinarily well investigated. Several months later, however, the magazine printed a half-page “clarification” indicating that any connection between early polio vaccines and AIDS is “one of several disputed and unproven theories.”200 Evidently, future vaccination campaigns and scientific reputations were jeopardized by the original story.

More examples of the intimidation and coercion ploy:

An Ohio woman with two children killed by the DPT vaccine received threatening letters from the Ohio Department of Health informing her that her only surviving child had to be vaccinated.201 A grieving mother whose baby died 17 hours after receiving a DPT shot was threatened with losing her WIC benefits for refusing to vaccinate her other children.(202)

A Kansas mother who objected to the vaccines was told that the state would seize her child, force the vaccinations upon her, and place her in a foster home. The child was vaccinated and is now permanently disabled as a result of the shot.(203)

This final example of the intimidation and coercion ploy clearly illustrates the arrogant and insensitive nature of the medical community. Grieving and dejected parents who personally contact the Vaccine Adverse Event Reporting System to report how their child was damaged or killed by a vaccine should be forewarned to expect an envelope in the mail with the following bold red letters emblazoned across the front: IMMUNIZE EARLY!(204)

14. The Godfather ploy is an extreme variation of the intimidation and coercion maneuver. It may involve blackmail. For example, poor mothers on state aid in Maryland must now get their children vaccinated or the state will take $25 from their monthly welfare checks for every preschool child not up to date on shots and checkups. A family sanctioned for three months will receive a call from a social service worker, who will request to visit the home to “help resolve the situation and any other problems.” Whereas child advocate groups claim Maryland’s new law is punitive and unfair, the state’s human resources secretary argues that “many [of these welfare recipients] just needed a push to do what is expected of them as responsible parents.”(205)

Here is another example of the godfather ploy: Health insurance companies are threatening to cancel policies when parents refuse vaccines for their children — unless parents sign a form absolving the insurance company from liability if the child contracts certain diseases.(206)

An extreme version of the godfather ploy — framing the parents — is now being reported with increasing regularity by frantic family members. Apparently, medical personnel intent on maintaining the vaccine deception will do anything to deflect blame. Moms and dads who are still grieving over their dead babies following the shots, are now being charged with homicide. For example, one mother, whose healthy baby died just 2 days after receiving DPT and MMR vaccines, was so outraged at this government sanctioned criminal activity, that she tried to fight back with a lawsuit. Authorities responded by charging her with the murder of her child.(207)

15. Scare Tactics. Whenever medical policymakers and their media pawns embark on a promotional blitz to increase vaccination rates, they invariably rely on the scare tactics ploy. Although this stratagem is similar to the intimidation and coercion ploy, subtle differences exist. Practitioners of the intimidation ploy seek mainly to dominate parental decision-making through the sheer force of their will. The scare tactics ruse attempts primarily to manipulate emotions and influence behavior by overstating sad and frightening stories about the unvaccinated.

One recently published pro-vaccine article describes in frightening detail the dangers of nonvaccination. First, readers are informed that “even adults can be killed from preventable infectious diseases.” Next, an emergency room nurse graphically recounts her attempts to restart the heart of a man who had contracted measles and continued to get sicker: A bacteria that usually causes strep throat “had invaded the small holes in the man’s skin” left by his measles rash. The man’s heart couldn’t be restarted, and he died from the secondary infection. Then, to clinch our emotions, we are told that he left three small children.(208)

Note: This very same measles vaccine that authorities claim could have prevented this tragedy, very likely caused it. Prior to the introduction of the measles vaccine, measles was a relatively tame childhood illness, and was virtually unheard of in infant, adolescent, and adult populations. But the vaccine changed all that. Now measles is contracted by age groups more likely to experience extreme complications, including death.(209,210)

A chickenpox vaccine has been available for years; however, authorities have been reluctant to approve it, for many people agree the disease is relatively harmless. Nevertheless, medical forces were prepared to approve it because “the U.S. could save five times as much as it would spend on the vaccine” by avoiding the costs incurred by moms and dads who stay home to care for their sick children. In response to the medical industry’s grand plans to promote this vaccine, media pawns rushed to print fearful stories detailing the dangers of this “serious” disease. For example, one newspaper published a personal story that started with “How my son died from chickenpox.” This scare tactic ruse was coupled with the “I (almost) forgot to mention” ploy, because the child had a preexisting condition that left him vulnerable to infection.(211)

Note: On March 17, 1995, the Food and Drug Administration (FDA) announced that it had approved a chickenpox vaccine.(212) Shortly thereafter, the American Academy of Pediatrics began recommending it for all infants.(213)

16. Euphemisms. Medical personnel often attempt to conceal the facts by using vague terms with hidden meanings — the euphemism ploy. For example, doctors have been notified by the CDC that cases of Hib may occur after vaccination, “prior to the onset of the protective effects of the vaccine.” [Translation: Our vaccine may give your child the disease.] Other studies warn of “increased susceptibility” to the disease in the first 7 days after vaccination. [Another veiled confession that the vaccine may give a child the disease.] In addition, children who contract a particular disease, even though they have received their shots according to the recommended schedule — an earlier schedule that has since been changed (see the variable recommendations ploy) — aren’t the victims of an ineffective vaccine, or a vaccine failure; instead, they were “inappropriately vaccinated.” These are labeled “nonpreventable” cases.(214-216)

In 1993, in England, two of the three MMR (measles, mumps, and rubella) vaccines in use at the time were quietly withdrawn because of what health authorities claim was a “slight” risk of “transient” meningitis.217 A recent study in the United States has determined that the risk of illness and death from childhood shots is real but “extraordinarily low,” leading authorities to conclude that these are “very rare events.”(218) Such remote and fleeting possibilities stand in stark contrast to the words employed by authorities interested in promoting their cause. Then we must be wary of the “poorly developed” immune systems of young children (as an argument in favor of the vaccines!), the “extremely infectious” nature of the virus, and the “grave risk of complications” associated with contracting the disease.(219,220)

More examples of the euphemism ploy:

Researchers are trying to develop a “magic bullet” super-vaccine “that could be given once at birth to immunize infants to all childhood diseases”(221)– delusions of grandeur. Perhaps they call it a “magic bullet” because infant deaths from the “shot” will remain a mystery to the medical scoundrels who pull the trigger.

The public is informed that vaccination rates increase by the time children enter school because parents are “motivated” — not compelled — to have their children vaccinated.(222)

Finally, be wary whenever authorities announce that an “unprecedented” or “experimental” vaccine will soon be available. What they really mean is, “we’re seeking human guinea pigs to study the effects of our newest concoction.”

17. Outright Lies. Lying is an established ploy of the medical community. It is a quick and easy way to promote the vaccine cause without having to rely upon honesty, morality, or ethics. Shrewd members of the medical fraternity know that very few people question doctors and their comrades.

The American Nurses Association recently collaborated with Every Child by Two, the Rosalynn Carter/Betty Bumpers Campaign for Early Immunization, “to educate nurses, parents, business leaders, civic organizations, and educators about the urgent need to immunize children.” Their aggressive stance against unvaccinated children includes a news release with the following claim: several childhood diseases — including polio, diphtheria, rubella, mumps, and tetanus — are undergoing a “resurgence.” This statement is an outright lie, obviously made to scare parents into vaccinating their children. None of these diseases is making a comeback. In fact, all are at their lowest rates of occurrence since records on their existence have been kept.(223)

According to Donna Shalala, President Clinton’s secretary of Health and Human Services, “This year’s flu, the Beijing strain, is expected to hit very hard.” She also claimed that 10,000 to 45,000 Americans lose their lives to influenza each year.224 However, official government statistics, which Donna Shalala oversees, contradict her claim. In 1991, the CDC reported just 990 deaths attributable to influenza; in 1992, 1,260. Americans die at rates 3 or 4 times greater from common diseases such as asthma (4,650 deaths in 1992), stomach ulcers (5,770 deaths in 1992) and nutritional deficiencies (3,100 deaths in 1992).(225)

18. Variable and Illogical Recommendations. Our children are being used as guinea pigs. To conceal this fact, authorities frequently change their recommendations. New and experimental vaccines replace old and ineffective ones. The number of doses and ages to receive them are altered on a regular basis as well, often with little rationale to justify either the original recommendation or the switch. For example, in 1985 the first Hib vaccine (haemophilus influenzae type b) was approved for general use in the United States and was quickly recommended for all children two years old and up —even though 75 percent of all Hib cases occur before two years of age! In 1988, a new “conjugated” Hib vaccine was approved for use in children at least 18 months of age. By 1991, its recommended use was extended to infants as young as two months old. Today, a genetically engineered Hib vaccine has replaced all earlier versions.(226-229)

In 1963, the recommended age for measles vaccination was 9 months. In 1965 it was changed to 12 months. In 1976 it was changed to 15 months.(230) However, since fewer moms have natural immunity to measles today — due to the large number of mothers who received childhood shots in the 1960s, 1970s, and 1980s — and therefore cannot pass protective antibodies on to their infants, outbreaks of cases are now occurring in children under 15 months of age.(231) In fact, by 1993, more than 25 percent of all measles cases were appearing in babies under one year of age.(232) As a result, in some areas of the country the recommended age to receive the measles vaccine was lowered again, bringing us full circle to initial recommendations — when most children were, according to medical authorities, “inappropriately vaccinated!”(233)

Recent data indicates that a large majority of measles cases are occurring in vaccinated people.(234) To conceal this fact, authorities rely upon the variable recommendations ploy and now recommend a measles booster shot at 4 to 6 years.(235) Some schools are requiring proof of revaccination before children can enter the 7th grade. Many colleges are refusing to admit students who have no evidence of revaccination. Yet, earlier studies — one recently published in the Pediatric Infectious Disease Journal — demonstrated that booster doses of the measles shot are relatively ineffective.(236,237)

Are altered recommendations based on sound science or personal convenience? Vaccine policymakers anxious to introduce the chickenpox vaccine were stymied by the number of vaccines already in existence. They could not decide at what age to recommend their new product. They wanted to make room for it at 15 months, but that would necessitate changing the third of four recommended ages to receive the oral polio vaccine from “15 to 18 months” to “6 months.” However, because there is “more leeway” with the MMR vaccine, they considered changing the first of three recommended ages to receive it from “15 months” to “12 to 15 months.”(238)

A “plasma-derived” hepatitis vaccination was introduced in the 1970s. In 1987, a genetically engineered “yeast-derived” vaccine was developed. In 1991, the CDC and AAP began the process of mandating the new vaccine for all infants — even though adult IV drug users, not children, are most at risk of contracting this disease!(239)

Here is one final example of the variable and illogical recommendations ploy: Authorities are so incensed by the number of people claiming vaccines damaged or killed a family member, that they are seeking to further restrict the stringent criteria for entering the National Vaccine Injury Compensation Program. For example, the newly revised rules stipulate that a severe reaction to a DPT vaccine — such as anaphylactic shock — must occur within 4 hours! In other words, if your previously healthy child receives the vaccine at 10 o’clock in the morning, has a violent allergic reaction — gasps for air, collapses into unconsciousness — at 3 o’clock that afternoon, and is later diagnosed as brain damaged, the federal government will say that the damage is not related to the shot and therefore you don’t have a claim. Other criteria for entering the program have been restricted as well, or removed altogether.(240)

19. Adjustable Diagnoses and Exaggerated Epidemics. Health officials realized early on that vaccine efficacy rates could be maximized by creative diagnoses. Remember, “the credit of vaccination is kept up statistically by diagnosing all the [cases of smallpox after vaccinations] as pustular eczema [or anything else] except smallpox.”(241) In other words, if the nonvaccinated contract the disease, call it one thing; if the vaccinated become ill, name it something else.

The medical profession often goes to great lengths to create the illusion of extraordinary vaccine efficacy rates. As an example, the standards for defining polio were changed when the live-virus polio vaccine was introduced. The new definition of a “polio epidemic” required more cases to be reported (35 per 100,000 instead of the customary 20 per 100,000). At this time paralytic polio was redefined as well, making it more difficult to confirm, and therefore tally, cases. Prior to the introduction of the vaccine the patient only had to exhibit paralytic symptoms for 24 hours. Laboratory confirmation and tests to determine residual (prolonged) paralysis were not required. The new definition required the patient to exhibit paralytic symptoms for at least 60 days, and residual paralysis had to be confirmed twice during the course of the disease. Finally, after the vaccine was introduced cases of aseptic meningitis (an infectious disease often difficult to distinguish from polio) were more often reported as a separate disease from polio. But such cases were counted as polio before the vaccine was introduced.(242,243) The vaccine’s reported efficacy was therefore skewed.

More recently, two siblings contracted a bad cough, and they were brought to the family doctor for a checkup. In a separate visit, their 2 cousins, who also contracted a bad cough, were brought to the same doctor. Prior to being examined, the doctor asked each set of parents the vaccine status of their children. The first 2 children, who were not vaccinated, were diagnosed as having pertussis. The other 2 children, who had been vaccinated against pertussis, were diagnosed as having bronchitis. No clinical test was performed on any of the children.(244) This tactic serves two functions: 1) it inflates whooping cough statistics suggesting the need for a pertussis vaccine, and 2) it suppresses the truth that the vaccine is ineffective.

Babies who die soon after receiving vaccinations are often diagnosed with Sudden Infant Death Syndrome (SIDS). In fact, this tactic is so handy that coroners are permitted to use this term to certify toddler deaths up to the age of 24 months.(245,246)

Vaccine epidemics are often “created” when health officials misdiagnose ailments, or overstate the number of cases. As an example, when television programs challenged the safety of the pertussis vaccine, the Maryland Health Department deceived the public by blaming a new “epidemic” of whooping cough on the impact of these shows. When Dr. J. Anthony Morris, former top virologist for the U.S. Division of Biological Standards, analyzed the original data, however, he concluded the Maryland epidemic didn’t exist. In only 5 of the 41 cases was there reasonable evidence to correctly diagnose whooping cough. And each of these 5 children had received from one to four doses of the pertussis vaccine.(247)

In Placitas, New Mexico, headlines warned parents of a dangerous whooping cough “epidemic” in that town. But only three cases of whooping cough were discovered, two of them in siblings, all three of them in children who were vaccinated.(248)

20. Patriotic Duty and Social Responsibility (also known as the Guilt Trip). According to Dr. Martin Smith of the American Academy of Pediatrics (AAP), “children of the nation are soldiers in the defense of this country against disease.”(249) Vaccine advocates maintain that some children must be sacrificed “for the welfare, safety, and comfort” of the nation.(250) One mother, whose child was permanently brain damaged within hours after receiving a DPT vaccine, was told by the family doctor that this was the price her child had to pay to keep other children safe. According to Dr. George Flores, Sonoma County public health officer, parents who reject vaccines “don’t consider the effect of their child on the rest of society.”(251) Apparently, unvaccinated children are a danger to everyone who is vaccinated, even though the vaccinated are supposed to be “protected.” (We are told that for the shots to work, everyone must play along.)(252) And families who decline the shots, we are told, are somehow reaping the benefits from those who dutifully have their children vaccinated.(253)

21. Unethical Experimentation. In December 1990, a federal regulation was adopted whereby the FDA gave permission to the U.S. Department of Defense (DoD) to circumvent U.S. and international laws forbidding medical experiments on unwilling subjects. This is the decree that allowed the DoD to inject American Gulf War troops with unapproved experimental drugs and vaccines without their informed consent by deeming it “not feasible” to obtain the soldiers’ permission.(254) Today, many of these vets, their spouses, and their children, are crippled by unknown diseases.(255)

In a class action lawsuit, American Indians in South Dakota are suing the FDA and CDC for testing a new hepatitis A vaccine on their infants. Health officials did not warn the parents the exposed children would be at risk for cancer, convulsions, eye disorders, or death.(256) Authorities now plan to test hepatitis A vaccine on remote Northwest Alaska villagers.(257)

Simultaneously administered vaccines have not been proven safe, yet authorities continue to recommend them and medical health practitioners continue to inject them. A recent study in the Journal of the American Medical Association found lowered levels of pertussis antibodies in children who were simultaneously given the DPT and Hib vaccines. According to the author of the study, “This concern must be addressed, for obviously we do not want to expose our children to the risk of vaccines without providing them with optimum benefit.”(258)

Every year during the fall and winter seasons a new flu virus is thought to circulate throughout the community. To produce a vaccine for this virus, health officials must correctly predict nearly a year in advance which virus will arrive (causing some people to speculate that when officials guess correctly, it’s really the vaccine itself that may be spreading the disease). With production usually beginning in January, and the final product licensed by the FDA in August, just a month or two before the shots are distributed, who does it seem the vaccines are being tested on?(259)

Vaccine researchers perform unethical experiments on human populations whenever their newest creations are ready to be tested. Therefore it comes as no surprise to learn of their plans to add foreign substances — viral matter — to the food supply. In fact, biotechnology firms have been experimenting with adding vaccines to bananas, lettuce, potatoes, tomatoes, and soybeans for several years now.(260,261) Who do you think these vaccines will be tested on?

22. Mandates. If vaccines are so wonderful, why does the government need to mandate them? You’d think that everyone would be lining up to get the shots. But vaccination rates are modest. The Clinton administration claimed that the price and accessibility of vaccines were hindering parents from maintaining vaccine schedules.(262) However, according to a survey conducted by The Gallup Organization on behalf of Lederle Laboratories, a major vaccine manufacturer, the “cost and time involved are least important” considerations for parents deciding whether to vaccinate their children. “The possibility of side effects is most frequently rated as important in making the decision.”(263)

State laws require children to be vaccinated before they can enter public school — unless a parent signs a waiver indicating opposition to the shots. While some states offer a philosophical or religious exemption, all provide a medical exemption — if contraindications exist. But parents should not have to sign a waiver objecting to mandatory vaccines. Instead, those who elect to have their children vaccinated should be obligated to read the full range of possible adverse reactions. Then, parents who still elect to have their children vaccinated should be required to sign a form indicating that they understand all the risks involved.

Mandating vaccines is also an unscrupulous means of extorting money from trusting parents. Imagine the exorbitant profits of any company that produces a product everyone is required by law to buy — even against their will. Moreover, the extreme wealth acquired through this medical racket is not hoarded by the drug makers alone; common doctors share in the booty. According to the late Dr. Robert Mendelsohn, world-renowned pediatrician, vaccines are the “bread and butter” of pediatric practice.(264) Others speculate that the damage caused by the shots may be responsible for new ailments and rare diseases(265-267) — enough to keep medical specialists affluent and busy for years to come.

Imagine for a moment a group of nutritionists who develop a multivitamin. They place their own people in a position to evaluate the benefits and risks of the product. It is now “officially” declared safe and effective. In fact, children who take this new multivitamin are reported to be 50 percent healthier than other children. But there is a catch: the costly vitamins must be taken at regular intervals and everyone must take them or they won’t work. They won’t enhance health, we are told, because the disease-prone “unprotected” children — progeny of irresponsible parents — will pass their germs on to the “protected” children — children of “responsible” families. So the nutritionists lobby government officials to mandate their product. Busy lawmakers study the “official” study results, determine that “protecting” children is a high priority, and decide to support the goals and ambitions of this powerful lobbying force.

Imagine any coalition of professionals with an agenda to pursue. Say, a guild of hypnotists has determined that children can be hypnotized to perform better in school than children who are not hypnotized. But again there is a catch: the children must be taken from their parents at regular intervals to be hypnotized, and all children must be hypnotized or the effects will be incomplete. Would you agree to this practice? Mind control, body control; who has authority over our children?

23. Refusing to Report Vaccine Reactions. Despite a federal law passed by Congress in 1986 — the National Childhood Vaccine Injury Act — requiring all doctors who administer vaccines to report vaccine reactions to federal health officials, many choose to ignore this legal requirement. Doctors often justify their refusal to report vaccine reactions by claiming the shot had nothing to do with the child’s injury or death. The will of Congress is being subverted, resulting in a gross underreporting of vaccine injuries and deaths.(268)

The Vaccine Adverse Events Reporting System (VAERS) is the federal program designated to tally reports of vaccine injuries and deaths. By the year 2002, tens of thousands of reactions to vaccines, including deaths, were reported — despite the medical boycott against reporting incidents.(269) Still, one must magnify these figures tenfold, because the FDA estimates that 90 percent of doctors do not report incidents.(270)

To further confirm the degree of underreporting that occurs, in 1988 and 1989 Connaught Laboratories conducted a study to determine the true rate of adverse events associated with the vaccines they produce. During this period of time, unsolicited (“spontaneous”) reports of adverse events occurred at the rate of 20 per million doses. However, when they supplied the vaccine to doctors with a request to report any adverse event that occurred within 30 days of a vaccination, provided that it resulted in a physician visit, the rate of adverse events skyrocketed to 927 events per million doses. According to Dr. Jim Froeschle, director of clinical research at Connaught Laboratories, these differences indicate “a fifty-fold underreporting of adverse events.”(271) Yet, even this figure may be conservative. According to Dr. David Kessler, M.D., director of the Food and Drug Administration, “Only about one percent of serious events [adverse drug reactions] are reported to the FDA.”(272)

The following testimonials from parents and relatives of vaccine-damaged children illustrate how easily doctors can dismiss apparent vaccine reactions and thus justify not reporting them:

“Our son had his 2nd DPT shot and oral polio [vaccine] at four months of age on September 22, 1989. He had reacted to his 1st DPT immunization two months earlier with prolonged high-pitched screaming and projectile vomiting…. After his 2nd shot he immediately started the high-pitched screaming again. He could no longer hold his head up and could not keep his food down. He couldn’t sleep or stay awake, he had absence seizures, dozens to hundreds a day. He deteriorated daily and died April 14, 1990.” The doctor would not report this reaction. He did not feel that it was related to the vaccine.

“Our 16-month-old grandson received his 4th DPT shot on December 5, 1989, and he died 24 days later. He also received the MMR and oral polio vaccines at the same time. Within 24 hours his legs were red and swollen, he had a fever of 103 degrees, and he was very fussy and irritable…. His previous shots had similar reactions…. We know the shot contributed to his death.” The doctor would not report this reaction. He did not feel that it was related to the vaccine.

“We lost our beautiful, precious and adored 4-month-old son 26 hours after receiving the DPT vaccination and oral polio [vaccine] at his well-baby checkup on January 25, 1990…. We were aware our son’s behavior patterns changed after the shot…. He was staring, looked spacey, only took short naps, vomited his bottle…. The doctor was insistent that this was a SIDS death.” The doctor would not report this reaction. He did not feel that it was related to the vaccine.

“Our son had his 1st DPT vaccination and oral polio vaccine at 14 months old on February 22, 1990. That evening he started high-pitched screaming. The next two days he had a temperature of 101 degrees and slept for 15 hours. When he awoke he was extremely irritable…. My son was in a lot of body pain. At times he looked like he had a stroke. At other times he was curled up in a hard knot we couldn’t straighten. He was having seizures and we didn’t know it…. He continues to have seizures. The doctor, even though law required him to record manufacturer and lot number, did not record the number.” The doctor would not report this reaction. He did not feel that it was related to the vaccine.

“My son had his first DPT shot at his 2-month checkup on May 8, 1990…. Four hours later he started crying…. I noticed he was pale and like a statue…. He stopped breathing. I picked him up and shook him and he started breathing again. A friend was visiting and called 911. My son stopped breathing 8 to 10 more times with me shaking him out of it each time before the paramedics arrived. He was ash white…screaming when we got to the hospital…. I have another child who had severe reactions from his shots. He had a seizure after each of his first three DPT shots and was on medication for three years.” The doctor would not report this reaction. He did not feel that it was related to the vaccine.

“My 16-month-old grandson had his 2nd DPT shot, MMR, and polio at his well-baby checkup on August 16, 1990. In less than 48 hours he had a temperature of 105 degrees and went into convulsions…. My grandson has deteriorated daily. He walks stiff-legged, or his knee collapses on under him…. He has trouble with his bowels, constipation one minute followed by diarrhea running down his leg the next minute. We look at our old videos and realize how much he has changed.” The doctor would not report this reaction, nor would he give the parents the manufacturers, and lot numbers of the vaccines he administered.

“My grandson had his 1st DPT shot and oral polio [vaccine] at his 2-month well-baby checkup on June 8, 1990. Within 21 hours he was dead. After the shot he started crying [high-pitched screaming]…. My grandson began projectile vomiting and continued the high-pitched crying…. At 7 A.M. my daughter awoke and found my grandson to have a purple color on one side of his face, clenched fists, blood coming from his nose and mouth and not breathing. My grandson was dead. I have promised my daughter that his death will not be in vain and just another statistic labeled SIDS.” The doctor would not report this reaction. He did not feel that it was related to the vaccine.(273)

24. Suppress Information/Prohibit Conflicting Testimony. On April 1, 1993, several bills were introduced in Congress to establish a federal “tracking and surveillance” system that would monitor parents who choose not to vaccinate their children. A few weeks later, Representative Henry Waxman and Senator Ted Kennedy chaired “public” hearings on this legislation, but prohibited input from individual parents, parent organizations, and healthcare professionals concerned about vaccine safety. Instead, only groups with a vested interest in ratifying these bills were permitted to attend: White House sponsors, several presidents of multibillion dollar companies that produce vaccines, agents of the American Academy of Pediatrics, and public health officials.(274)

The Salk “inactivated” or “killed-virus” vaccine was actually regulated to permit 5,000 live viruses per million doses. Yet, because the vaccine was promoted as being incapable of causing polio, cases that occurred following administration of the vaccine were denied, and it was excluded from the Vaccine Injury Table.(275) The CDC also refuses to acknowledge occurrences of encephalitis and seizure disorders following administration of the oral polio vaccine, even though encephalitis has been known to occur following polio contracted under natural conditions.(276)

More examples of the suppression ploy:

A recent report published in Lancet notes that some people contract meningitis after receiving the MMR vaccine. Nevertheless, the author concludes that “because of the extreme rarity of this complication, parents need not be told about the risk before deciding on vaccination.”(277)

Even though a national drug evaluation committee (ADRAC) recommended that children should be observed for a sufficient period of time after vaccination to monitor reactions, authorities fought against the suggested period of observation on the grounds that it causes inconvenience to parents and increases anxiety about the safety of childhood shots.(278)

When the National Childhood Vaccine Injury Act of 1986 was passed into law, the Department of Health and Human Services (HHS) was ordered by Congress “to develop and disseminate vaccine information materials for distribution by health care workers.” This material was to include information on adverse reactions, contraindications, and the availability of a federal compensation program for people who are injured or die from a mandated vaccine. HHS was to satisfy this legal requirement by December 22, 1988. By March 4, 1991, this matter was still unsettled. When HHS eventually submitted the required information, “they failed to meet even minimal standards of scientific rigor, candor, and fairness.” Vaccine risks were systematically understated or ignored.(279)

Although medical personnel are required by law to provide their clients with information booklets explaining the benefits and risks of vaccinations before they receive their shots, few doctors offer these booklets to their clients. The following story illustrates the type of damage that can occur when healthcare providers choose to suppress lifesaving information:

“I am a 29-nine-year old female who received an MMR vaccine required by [the medical center where I work]. Since receiving that vaccine I’ve experienced a number of side effects: dizziness, headaches, numbness of my feet and ankles, shortness of breath, chest pain, and aching joints.

“I have seen several doctors over the last six months, more times than I can count. Those doctors that admitted the vaccine may have something to do with these symptoms felt that within six months the symptoms would subside. Unfortunately, this is not the case. In fact, some symptoms have gotten worse. My ankles are numb almost continuously, the chest pain has begun to include pain in my left arm and jaw, accompanied by difficulty breathing.

“Every aspect of my life has been affected by this, including my work ability, which is the reason I had to have the vaccine in the first place. I was told I either had to get it, or I wouldn’t have a job. Unfortunately, by this time I have already given up the job I held for over five years.

“I was not given any information prior to receiving the vaccine. [I later learned] that people allergic to eggs should not receive this vaccine. I am allergic to eggs, but the hospital staff never asked or told me anything. My primary care physician is at a loss about what to do with me. But I continue to suffer.”(280)

25. Psychological Projection. Medical personnel are notorious for seeing in others the very thoughts, feelings, and actions they deny in themselves. This subtle and unconscious defense against anxiety and guilt is what psychologists refer to as projection. Vaccine researchers, for example, are disappointed that women and minorities have been reluctant to be experimented on with a new AIDS vaccine, even in light of recent revelations about Cold War radiation tests on unwitting subjects. The reluctant volunteers — not the researchers — were blamed for harboring a “mistaken belief” that the vaccine could cause AIDS, despite what the scientists say.(281)

Note: Less than 5 months later, researchers were forced to acknowledge that “at least five volunteers in the government’s principal AIDS vaccine study have become infected with the AIDS virus after receiving the vaccine.” One of the subjects is said to have undergone “an unusually rapid decline in the number of white blood cells, the standard measure for the progress of AIDS.” This has raised researchers’ concerns “not only about how well the vaccine works but whether it may have increased the likelihood of their infection and…even accelerated the progression of disease.”(282)

Medical policymakers and some lawmakers claim parents are abusing their children by not allowing them to be vaccinated.(283,284) Some parents have been accused of child abuse — “shaking baby syndrome” — after their children had seizures or went into a coma following vaccinations.(285) In fact, the authorities who allow these dangerous vaccines to be administered are abusing the children and implicating the parents. Parents have lost custody of their loved ones in this manner.(286)

26. Organized Propaganda. Community organizations and parent groups are often enlisted by medical associations to help organize campaigns against unvaccinated children. “Volunteers” rarely question the cult-like doctrines the pro-vaccinators foist in their direction. But are these organizations, and their helpers, really doing the community a service? How honest are vaccine campaigns that omit mention of the thousands of families affected every year by adverse reactions to vaccines? Why are the true facts prohibited from being revealed? And why can’t parents be trusted to weigh the facts for themselves?

The medical-industrial complex is well-prepared for almost any unfavorable eventuality that may occur. For example, soon after the NBC television show “NOW” broadcast a story about the dangerous DPT vaccine, a DPT manufacturer sent telegrams to health professionals throughout the nation reassuring them of the vaccine’s safety.(287) After the show aired a second time, the CDC organized a propaganda blitz by swiftly faxing biased pro-vaccine information to doctors and other concerned people throughout the nation. In this fax, the CDC had the audacity to claim that “Almost all infants with any medical illness, including death, will have been vaccinated earlier in their life…. [and] Almost all infants with any medical illness, including death, will have drunk milk earlier in their life,”(288) implying that receiving shots is as benign as drinking milk.

27. Legal Immunity. When the FDA tested a batch of DPT vaccine, they found the entire lot to be 200 percent more potent than regulations allowed. Instead of immediately destroying it, the agency allowed health authorities to “test” it on hundreds of children in Michigan. This proved to be a tragic gamble. Later, when the parents of children who were paralyzed and brain damaged from the mandatory shots tried to sue the state, the courts disallowed their case because the “doctrine of sovereign immunity” protects the government from claims arising from services that only the government can provide.(289)

A 13-year-old Pennsylvania girl suffered irreversible brain damage from a measles vaccine received during a mandatory mass vaccination program at her school. However, a court decision made it clear that neither the vaccine manufacturers nor the government could be held responsible because the vaccines were “unavoidably unsafe.” [Translation: Parents are compelled to play the medical establishment’s unique brand of Russian roulette.] The court also claimed the vaccine maker adequately delineated risks on its package insert.290 Consequently, these parents were deemed solely responsible for the care of their now mentally retarded daughter — even though they, like most parents, were not warned about vaccine dangers, were not told about these inserts, and withheld permission for their daughter to be vaccinated!(291)

Drug companies are legally immune against most claims of vaccine damage, and their incentive to produce safer vaccines was removed when the National Childhood Vaccine Injury Act of 1986 was passed. This law states that “no vaccine manufacturer shall be liable in a civil action for damages arising from a vaccine-related injury or death.” Incredibly, the original draft also stated: “The term vaccine-related injury or death means an illness, injury, condition or death associated with one or more of the vaccines listed in the vaccine injury table except that the term does not include an illness, injury, condition or death associated with an adulterant or contaminant intentionally added to such a vaccine.”(292)

28. Threats to go out of Business. Before the National Childhood Vaccine Injury Act of 1986 was enacted, vaccine manufacturers were being sued so often and for so much money, that many threatened to — and did — go out of business.(293) When the government began accepting liability for vaccine injuries and deaths, the enterprising drug companies succeeded in removing an important incentive to produce safe and effective vaccines.

29. Stonewalling. Vaccine officials use the stonewalling tactic whenever they want to delay or avoid accepting accountability. For example, when one mother, whose son died four days after his second polio shot, studied his provisional autopsy report, she noted that there were major findings of myocarditis, and hepatitis, and that the polio virus had been extracted from these diseased organs — conditions not inconsistent with a vaccine reaction. But when she questioned the pathology department’s initial conclusion — Sudden Infant Death Syndrome — and requested additional tests to determine whether the polio virus was a wild or vaccine strain, she was led into a nine-year battle with the CDC to secure the results. (Medical authorities were forced to concede the truth: the vaccine caused the child’s polio.)(294)

When a child is killed by a mandated vaccine, the government is expected to compensate the parents, awarding them up to $250,000. However, if the child is seriously injured by the vaccine, continues to live, and requires lifetime care, several million dollars may be awarded. Government officials may be reluctant to settle cases quickly, hoping the damaged child will die, thereby lowering the payment. This is exactly what millions of people learned when The Crusaders, a television newsmagazine, aired a gutsy show on the dangerous pertussis vaccine. The father of a young boy who suffered severe and permanent brain damage just hours after a DPT shot could not get the government to settle his case. The family needs the money to pay for the child’s specialized care, but “if something were to happen to him and he did not live, they would not have to pay for his life care.”(295)

30. Secrecy. If vaccines offered benefits only, the government wouldn’t need to mandate them, and the ploys noted in this chapter wouldn’t be necessary. Instead, parents would be lining up to get the shots. Members of the medical fraternity realize this, and have banded together to conceal how the vaccines are made, who they’re tested on, how effective they really are, and the true rates of adverse events. Even the manufacturer’s cost to market vaccines is considered a “trade secret or confidential information.”(296)

Doctors who have dared to publicly question vaccines, “have been warned that their careers are at stake and they risk [losing their license to practice medicine].”(297) Others are discredited.(298)

After one family’s son was damaged by a DPT shot, they obtained, through the Freedom of Information Act, a computerized record of more than 34,000 adverse reactions to vaccines over a three-year period. They had a hunch their son had received a bad vaccine — from a “hot lot” — and wanted to see if they could protect other children from being hurt.

After a great deal of research, they discovered that their son had been vaccinated from a hot lot. The death rate associated with this batch was three times higher than that linked with other lots. Ten children had died from it. But when the parents spoke to officials at the FDA to determine if the agency would conduct an investigation, they were told that “due to the size of the lot, the deaths did not warrant significant investigation.” When they inquired about the size of the lot, the FDA flatly stated, “That’s confidential.”(299)

Parents everywhere would like to know how many deaths would be enough to warrant an investigation. If ten isn’t enough, is twenty? Thirty? Forty? What’s enough? What industry is permitted to operate in secrecy, and put out a product to the public without accountability? Concerned citizens cannot even find out from the government what the mechanism is to institute a recall, if indeed one even exists.(300)

Drug company awards for vaccine damage are usually settled out of court. Parents who expect to receive compensation for their child who was damaged or killed by a vaccine are often obligated to remain silent as a condition of the agreement. Parents seeking compensation from the Federal Vaccine Injury Compensation Program are often counseled to refrain from discussing their cases, and settlements, as well.(301) To learn how difficult it is to break the secrecy pact, try to obtain specific vaccine information from the CDC or FDA. They’ll be happy to send you their official propaganda but will quickly turn apprehensive and restrained when you start probing for additional information. These public organizations, supported by taxpayer dollars, have all sorts of information. However, they’re unlikely to share it with average citizens, for then we’d be able to make our own rational, informed decisions regarding the shots. But the American people are entitled to know the answers to their questions before submitting their children to “mandated” vaccines.



“We could kneel on broken glass and give the American Medical Association (AMA) everything it wanted, and still they will oppose it. They are going to push us as far as possible, and then they are just going to screw us.” –Federal Healthcare Task Force Member, Time, (September 20, 1993), p. 61.
“Every doctor will allow a colleague to decimate a whole countryside sooner than violate the bond of professional etiquette by giving him away.” –George Bernard Shaw



This article was excerpted from the vaccine archives of Neil Z. Miller.
See Immunization Theory vs. Reality for more information.
Copyright © 1995-2003. All Rights Reserved.

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February 24, 2008 Posted by | Health, Vaccines | , , , , , , , , , , , , , , , | Leave a comment

Indonesia accuses US of bird flu plot

Indonesia accuses US of bird flu plot

Mark Forbes Herald Correspondent in Jakarta
February 20, 2008

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THE Indonesian Health Minister has said the United States and the World Health Organisation are part of a global conspiracy to profit from the spread of bird flu and the US may use samples to produce biological weapons.

The views of Dr Siti Fadilah Supari, outlined in her new book, threaten to undermine efforts to control the spread of avian influenza. With 104 deaths, nearly half the world total, Indonesia is the new hotspot for the virus.

Despite claims by the minister that she has agreed to share virus samples and allow all nations access to resulting vaccines, Indonesia is still blocking sharing samples from human victims.

Applications to send more than 200 samples from chickens to an Australian laboratory had also been refused, inquiries by the Herald have revealed.

In the book, Dr Supari writes that WHO laboratories forwarded influenza viruses to Western companies so they could profit by selling vaccines back to developing countries: “The system of world health management has been very exploitative. It has been controlled by inhumanly desires, based on the greediness to raise capital and to control the world.”

Some Indonesian samples had been sent to a US Defence Department laboratory, Dr Supari says, adding that “some of our seed viruses had been in a laboratory known as a facility developing biological weapons in a superpower country”.

Privately, officials said Dr Supari’s belief that she was engaged on a God-driven crusade against an evil and “neo-colonialist” world health system – on the book’s cover she describes herself as the “divine hand behind avian influenza” – had caused her to lose touch with reality.

The President, Susilo Bambang Yudhoyono, appears to have endorsed the book, having written its introduction.

Dr Yudhoyono supports Dr Supari’s claim that the virus is under control in Indonesia, stating the “occurrence rate and the number of affected areas are decreasing”.

The WHO declined to comment and no US officials were available.

This story was found at: http://www.smh.com.au/articles/2008/02/19/1203190823829.html

February 21, 2008 Posted by | Conspiracies, Government, Health | , , , , , , , , , , | Leave a comment

Ecklonia Cava Extract – Super Antioxidant & Beyond

 Ecklonia Cava Extract – Super Antioxidant & Beyond

Ecklonia Cava Extract: Polyphenol / Phlorotannin Derived from Brown Algae

 Disclaimer: For educational purposes only This information has not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease

Ecklonia Cava Extract (ECE) is a standardized natural complex of unique marine molecules that originate from a specific species of brown algae (Ecklonia cava). ECE represents a unique category of polyphenols often called phlorotannins. Their unique polyphenolic structure endows them with biological activities that are not found in land-based plants.

ECE naturally occurs as high-molecular weight tannin (Mw> 2,000 Dalton) and low-molecular weight tannin (Mw=400-1000 Dalton). ECE can be classified into four types depending on the ratio of high molecular weight and low molecular weight tannins. Various physiological activities of ECE have been evaluated in vitro, in vivo and clinically as individual compounds (ECE1-ECE14) and complex forms (ECE, Type I-IV).

Millions on Research

Dr. Haengwoo Lee and his team of M.D.’s and Ph.D.’s have spent over thirty million dollars on research, from in vitro to animal and human studies. Much of the work was done in Korea, and some at the University of Washington. ECE has been found to be an impressive therapeutic agent in a wide array of clinical applications.

SUPER ANTIOXIDANT

The power of an antioxidant is determined by its structure, which is made up of rings. These rings capture stray electrons from free radicals. Most flavonoids generally have three interconnected rings. ECE has up to eight interconnected rings, making its free-radical scavenging ability 10-100 times more powerful than other polyphenols. It is substantially more powerful than green tea catechins, which only have four rings.

Multiple Antioxidant Profiles of ECE

ECE’s antioxidant activities against various reactive oxygen species have been confirmed to be highly potent in physiologically relevant concentrations. The effective dose of ECE for free radical scavenging is in the 10-20 µg/mL range which belongs to most potent families of natural antioxidants. ECE itself and its individual compounds have demonstrated potent reducing power and radical scavenging activities against DPPH radical, oxidized LDL and peroxynitrite.*

Much Longer Half-Life

ECE is a unique polyphenol in that it has a very long half-life in the body. This is because ECE is a marine-based polyphenol which is 40% fat-soluble. Virtually all other polyphenols are derived from land-based plants and are water-soluble. The half-life of ECE is up to 12 hours, compared to 30 minutes for water-soluble, land-based polyphenols. ECE has the ability to cross the blood-brain barrier.

The Research of Martin Pall, Ph.D.

Peroxynitrite is the most notorious of the free radicals incriminated by Martin Pall, Ph.D.’s groundbreaking research on multiple chemical sensitivity, fibromyalgia, chronic fatigue syndrome, post traumatic stress disorder, Gulf War syndrome, and fourteen other conditions. Peroxynitrite plays a main role in Dr. Pall’s mechanism, along with NF-kappaB and other inflammatory mediators. ECE also reduces tissue specific NF-kappaB.

*Peroxynitrate is a central reactive oxidant, which appears to play a major role in many disease processes.

FIBROMYALGIA

ECE: Phase I Clinical Trial Results (Preliminary)

In an 8-week, double-blinded, placebo-controlled study of established fibromyalgia patients, ECE was used as an adjunct therapy to the patients’ current standard of physician care. The results established the general safety of ECE. ECE cut the time it took the participants to fall asleep by 47 minutes; it increased total nighttime sleep by 1.6 hours; it improved soundness of sleep by 80%; it boosted their energy levels by 71%; it gave them 2 1/4 more good days per week; it helped reduce their pain by 31%; and their general condition improved by 39%. Interestingly, these improvements were achieved at all doses. Patients given the placebo had no improvement during the study.

ECE & FIBROMYALGIA

BRAIN FUNCTION: MEMORY, RELAXATION, ALERTNESS

Acetylcholine & Memory

Memory is dependent on the neurotransmitter acetylcholine (ACh). In an animal study, ECE increased rodent ACh by 140% in brain regions responsible for learning and memory in seven days. Memory enhancement increased by 100-200% at an oral dose as low as 0.2-1mg/kg.

With regard to mechanism, it is thought that the mild acetylcholinesterase inhibitory activity of two phlorotannin compounds found in ECE, dieckol (DE) and phlorofurofucoeckol (PFF), may be involved in the up-regulation of acetylcholine.

Increased Blood Flow

ECE crosses the blood-brain barrier and significantly improves blood flow, which is likely another way ECE improves memory. More specifically, Dr. Lee’s group found that ECE can increase the velocity of blood flow in the carotid artery from an average of 36.68 cm/sec. to 40.09 cm/sec., while the placebo showed no improvement.

Relaxation & Alpha-Waves

An EEG study on brain waves of healthy middle age volunteers found that ECE compounds increase alpha-waves. Alpha-waves are an indicator of relaxation.

Alertness

Yet another study found that ECE compounds prevented sleepiness in bus drivers and in high school students during daytime activities. This is likely due to increased blood flow and oxygen delivery.

Neuroprotective Effects

ECE demonstrated powerful neuroprotective effects owing to several features of its components. ECE compounds are both powerful antioxidants and anti-inflammatory agents capable of scavenging free radicals and suppressing excessive inflammatory reactions. Fucoidan in ECE has recently been found to protect neuronal cells from ischemia-induced inflammatory reactions which often occur in the aged and highly stressed brain. ECE compounds also neutralize the neurotoxic free-radical peroxynitrite.

Enhancement of Acetylcholine Levels in Mice

After 7 days oral administration of two ECE compounds (DE 10mg/kg and PFF 2mg/kg), mice under ethanol-induced cognitive impairment showed substantial enhancement of acetylcholine in three brain regions related to memory formation, as compared with non-treated mice. Especially, 140% enhancement was observed in the frontal cortex that is crucial in long-term memory and associative thinking.

Resistance of Stress-Induced Learning Deficit in Mice

In a 5-day study, ECE treated mice showed significant resistance to electric shock treatment-induced learning deficiency, as compared to non-treated mice whose learning process was significantly retarded during the test period.

Memory Enhancement in Mice

The beneficial effects of ECE compounds on memory enhancement were further demonstrated by measuring the latency time avoiding the previously experienced electric shock treatment in mice as passive-avoidance memory testing. After 7 days oral administration of two ECE compounds DE and PFF (as low as 1 and 0.2mg/kg), mice under ethanol-induced cognitive impairment showed 130-140% improvement, especially in the PFF group.

Beta-Amyloid Deposition Inhibition in Rats

Researchers at the National Institute of Health’s aging research labs in Baltimore studied ECE in rats, and found it to inhibit beta-amyloid deposition in the brain. Beta-amyloid is the same substance that accumulates in Alzheimer’s disease. The rats also learned maze challenges faster, which demonstrated improvement in short-term memory.

ARTHRITIS, INFLAMMATION, NEURALGIA

Dr. Lee and colleagues found ECE to naturally suppress inflammatory responses and neutralize inflammatory damage caused by reactive oxygen species. The optimal combination of ECE’s natural anti-inflammatory and tissue-protective properties appears to enable dramatic improvement in both arthritis and neuralgia. In a human trial, ECE significantly reduced pain in a group of knee arthritis patients compared with placebo.

Comparable to Celebrex®

ECE’s ability to treat arthritis was found to be comparable to Celebrex®, the prescription drug that reduces inflammatory cox enzymes.

The influence of ECE in lipopolysaccharide (LPS)-induced generation of prostaglandin E2 (PGE2) using RAW  246.7 cells was studied. While PGE2 was barely detectable in non-stimulated cells, more than one hundred times the amount of PGE2 was detected in the stimulated cells. ECE, celecoxib (Celebrex®) and aspirin all showed significant inhibition of PGE2 generation in the concentration range tested. ECE showed inhibition of 61%, 85%, 92% and 99% at concentrations of 10, 30, 60 and 100 µg/mL, showing similar activity to celecoxib which showed 65%, 79%, 85% and 96%.

Cartilage Protecting Activities

As demonstrated above, ECE compared almost identically to celecoxib in the ability to reduce PGE2 by slowing down the lipoxygenase (LOX) system. ECE compounds have more than double the ability of resveratrol to inhibit LOX. These results were demonstrated in a study on rabbit cartilage cells. Those cells treated with ECE had up to an 80% reduction in degeneration.

Rabbit Model

In an animal study, rabbit articular cartilage explant culture was treated with recombinant human interleukin 1 (rhIL-1) to induce proteoglycan degradation. The amount of glycosaminoglycan released into the medium was measured as an index of proteoglycan degradation. When the rabbit cartilage explants were treated with rhIL-1 for 60 hours, the amount of released glycosaminoglycan into the culture medium increased significantly compared to the vehicle group (1.44 ± 0.06µg/mg vs. 0.30 ± 0.01µg/mg). Diclofenac, which is known as a selective COX-2 inhibitor was used as a positive control at a dose of 10µM (3.2µg/mL). ECE significantly interfered with the rhIL-1-mediated degradation of proteoglycan in all concentrations tested (p <0.001). It showed 53%, 79%, 81% and 70% of inhibition at 1, 3, 10 and 30 µg/mL concentration.

Neuropathy: 4-Week Clinical Trial

Researchers recently studied ECE on 40 patients with neuropathy. ECE reduced nerve pain by 40% in four weeks. Overall, 80% of the patients responded favorably.

Speculation about Neuropathy Mechanism

The strong lipid and cholesterol reducing potential of ECE supports reduced vascular inflammation. Increasingly, the scientific literature supports the notion that many forms of nerve pain or neuropathy are caused by nerve pressure, as exerted by swollen, inflamed blood vessels adjacent to the nerves.

ALLERGIES / ASTHMA

Overall, ECE appears to significantly relieve allergic reactions without drowsiness, dizziness and other side effects of anti-histamine drugs.

Allergic Inflammation: Mouse Model

Dr. Lee and his team found that ECE significantly reduced allergic inflammation in mice. Specifically, ECE reduced the migration of eosinophils to the lungs by 75%. Inflammatory white blood cells (CD4+4 T Cells, resultant cytokines Il-4, 5, 13) were reduced by 50%. Mucus plugs in the airways were reduced by 75%. Airway epithelial hyperplasia reduced by 75%. Collagen-causing fibrosis in lung interstitium (fibrosis, airway remodeling) and smooth muscle cell thickness was reduced by 20% and 32%. These latter findings suggest that ECE compounds can prevent or reverse the progression of chronic lung disease such as asthma and Chronic Obstructive Pulmonary Disease (COPD).

5-Lipoxygenase (5-LOX)

5-Lipoxygenase (5-LOX) catalyzes the first step in the oxygenation of arachidonic acid, thus leading to the production of biologically active compounds such as leukotrienes and 5-hydroxyeicosatetraenoic acid. The peptidoleukotrienes (leukotriene C4, leukotriene D4 and leukotriene E4) are powerful spasmogens, which have been implicated in inflammatory and allergic responses. Therefore, inhibition of 5-LOX is a medicinal target for the treatment of inflammatory diseases. One of the ECE compounds (8,8-BE) significantly inhibits 5-LOX compared with other well-known natural medicinal compounds such as resveratrol and EGCG.

University of Washington Asthma Mouse Model

The efficacy of ECE for asthma was demonstrated in an allergen-induced murine asthma mouse model by Dr. Emil Chi, Chairman, Department of Histopathology, University of Washington.

The researchers tested an ECE product (KLS) in a mouse model of allergen-induced chronic lung inflammation and fibrosis. BALB/c mice, after intraperitoneal antigen sensitization on day 0 and day 14, were given weekly intranasal inhalations of antigen from day 14-60. The antigen-treated and challenged mice developed an extensive eosinophil and mononuclear cell inflammatory response, mucus cell hyperplasia and mucus occlusion of the airway.

KLS was found to be effective in reducing allergic reaction in inflammation. By feeding at a concentration of 5.4 mg/ml in the drinking water for 12 days, KLS reduced the airway mucus plugging, and sub-epithelial fibrosis in the antigen-sensitized / challenged mice. The reduced BAL fluid eosinophil indicated that KLS is effective in improving the asthmatic lung structures. No pathological alterations in the liver, kidney, spleen, or small intestine were found.

CARDIOVASCULAR BENEFITS

Coronary Artery Disease

ECE has been shown to improve coronary artery disease (CAD). Researchers found that ECE is even more potent at inhibiting the oxidation of LDL cholesterol than green tea catechins, and appears to scrub the plaque off the endothelial lining. ECE also reduces vascular inflammation by preventing oxidation, which also directly effects inflammatory mediators such as inflammatory prostaglandins, etc.

Coronary Artery Disease: 6-Week Clinical Trial

A clinical trial using ECE was conducted confirming its capacity to regenerate vascular endothelium and recover plasticity of blood vessels after 6 weeks of treatment by measuring flow-mediated dilation (FMD) & nitroglycerin-mediated dilation (NMD) of normal and CAD patients with narrowed coronary arteries by 50+%. FMD indicates nitric oxide (NO) releasing ability of endothelial cells to expand blood vessels by detecting shear stress caused by incoming blood flow (low FMD value can indicate endothelium damage).

After 6 weeks of treatment with ECE, clinical data showed that FMD, the endothelium-dependent dilation, was greatly enhanced in the CAD group, indicating its remarkable activity of inducing recovery of endothelial cells. NMD, the endothelium-independent dilation, which represents the vascular plasticity, also showed remarkable improvement in the CAD group, again supporting ECE’s ability to support restoration of vascular integrity by reversing atherosclerosis.

Cholesterol: 6-Week ClinicalTrial

Researchers gave 39 adults (average age 55.6) low dose (100 mg) ECE compounds for six weeks. Their average cholesterol dropped from 228 to 224. LDL dropped from 141 to 135. HDL rose from 46.5 to 50.7 (highly significant). Triglycerides fell from 215 to 195, and the atherogenic index dropped 12.5%.

Some of the parameters from the above study show very mild changes, which in themselves, may not be statistically significant. However, all parameters went in a health-positive direction, so taken together, the changes in LDL, HDL, triglycerides, blood pressure, and antioxidant protection are very significant. Also, endothelial cells were protected against oxidative damage, and were able to produce significantly more NO, which dilates blood vessels. Dramatic increases in blood flow were also found at this low dose.

Hypertension: 4-Week Animal Study

The remarkable effect of ECE on vasodilation was clearly demonstrated in renovascular clipping induced hypertensive rats. Renovascular clipping surgery is known to increase ACE activity via the renin-angiotensin-aldosterone system, which increased systolic blood pressure (SBP) from 140 to over 200 mm Hg after 4 weeks. Upon oral administration of phlorotannin (99.4%, 50 mg/kg) or enalapril (commercial hypotensive drug, 10 mg/kg) SBP dropped to as low as 160 and 140 mm Hg. Upon cessation of treatment, SBP increased again in both cases. Although ECE showed a similar pattern to the drugs, it also showed a slower rebounding of blood pressure during the no treatment period, which indicates its potential as a vascular protector with prolonged oral administration.

ACE Inhibition

Angiotensin-converting enzyme (ACE), is responsible for conversion of angiotensin I to angiotensin II and degradation of bradykinin, and is a key component in the renin-angiotensin-aldosterone system. Angiotensin II regulates cellular proliferation, inflammation, and endothelial function, and is therefore important in the pathogenesis of atherosclerosis and its complications. Aging or various vascular risk factors tend to increase ACE levels resulting in excessive vasoconstriction and hypertension. Current hypotensive drugs block the action of ACE or its by-product angiotensin II.

ECE tannins have been found to be potent natural ACE inhibitors, demonstrating more than 15 times the power to inhibit ACE as the most powerful land-based polyphenols, including the natural hypotensive substance catechin found in green tea. One of the compounds found in ECE, THP-BE is comparable to the physiological vasodilative hormone bradykinin.

Antiplasmin Inhibition

Plasmin (a fibrinolytic enzyme that breaks down blood clots) is rapidly blocked by a protein called antiplasmin. ECE compounds are natural potent inhibitors of anti-plasmin, capable of efficient promotion of plasmin that performs fibrinolysis. ECE compounds have shown remarkable activity which is 40-200 times greater than synthetic compounds Flufenamate and Chloramine T. One study on ECE compounds found a small but significant rise in prothrombin time and a fall in fibrinogen levels.

ERECTILE FUNCTION – ECE V. VIAGRA®

Nitric Oxide

ECE can regenerate the vascular endothelium, the cells critical to the inner lining of the blood vessels. They generate the chemical nitric oxide (NO), which keeps the arterial walls relaxed and dilated. After a six-week study of ECE, flow mediated dilation and NO mediated dilation increased by 60% and 50%. In another study, coronary artery disease patients were given ECE for six weeks. Blood flow controlled by NO increased 50-60%. These results confirm that ECE can rejuvenate damaged endothelial cells to produce NO. This effect was further confirmed in a study on erectile dysfunction (see below). Interestingly, Viagra® works by increasing NO in the penile artery.

ECE v.Viagra®: 8-Week Clinical Trial

Scientists studied 31 men with erectile dysfunction (ED) for over six months. They compared eight weeks of ECE use to Viagra®. They looked at orgasmic function (OF), intercourse satisfaction (IS), overall satisfaction (OS), and erectile function (EF). Over those eight weeks, ECE scored 87%, 74%, 62%, and 66%. Viagra® scored 27%, 44%, 39%, and 66%. No side effects were reported with ECE:

Population with 25+% Improvement in IIEF (International Index of Erectile Function) score was as high as 81%. Total IIEF score significantly increased from 29.1 ± 13.1 to 47.0 ± 14.5 with 62% of improvement. When the IIEF scores were grouped into five separate domains, mean IIEF scores at the 8th week were significantly greater than those at week 0 for all domains (all p<0.01). The degree of improvement was significant in the following order: OF (87%), IS (74%), EF (66%), and OS (62%). Scores on key questions (asking frequency of penetration and asking frequency of maintaining an erection after penetration), which directly indicate the ability to achieve and maintain an erection sufficient for sexual activity, were improved up to 74% and 77%, respectively (p<0.01).

It is very important to note that despite the marginal improvement in sexual desire (20%) that is of psychological nature, great improvements were reported in the domains directly related with erection that is of physical nature and dependent on normal vascular function of the penile artery.

Also noteworthy, was a significant increase in the orgasmic function score (87%), intercourse satisfaction (74%) and overall satisfaction (62%) as well as erectile function (66%) in comparison with the results for sildenafil reported by Marks, et al. (Marks, et al., 1999) (27%, 44%, 39% and 66%, respectively), which indicates that ECE significantly contributed to the normalization of the general vascular conditions around the sexual organ.

These results strongly indicate that the long-term administration of ECE significantly contributes to the neutralization of oxidative risk factors, thereby improving peripheral blood circulation around muscles and nerves involved in sexual function as well as the penile artery. No side effects were reported.

Vasodilation & Erectile Function

It has been reported that vasculogenic ED patients have elevated levels of angiotensin II for the duration of the erection process. The demonstrated action of ECE on ACE and resulting vasodilation is thought to play an important role in inducing successful erectile function.

Long-Term Improvement Via Vascular Protection

As discussed, ECE phlorotanins have potent antioxidant and anti-inflammatory effects. Together with ECE’s ACE inhibitory activity, which is also beneficial to vascular homeostasis, these activities, upon long-term oral administration, may all contribute to supporting a healthy vascular system, including the penile artery.

WEIGHT LOSS

DGAT Inhibition

Diacylglycerol acetyl transferase (DGAT) is the enzyme involved in the final step of triglyceride synthesis. Triglycerides are circulating fat bodies that ultimately wind up in the fat cells, and are almost always elevated in diabetes. They also have emerged as a major risk factor in vascular disease.

Dr. Lee found that ECE compounds inhibited DGAT more than 50%. In genetically caused obese laboratory rats, ECE reduced body fat and increased physical activity. In another study, ECE caused leanness and fat-resistance in animals given a high fat diet.

ECE Beverage: 2-Week Clinical Trial

In a human study, 141 young adults were given a beverage containing ECE at 200 mg daily. In two weeks their average weight dropped nearly 2.5 pounds, muscle mass increased by nearly 2.5 pounds, and body fat dropped by 4 pounds, or 7.48%. ECE stimulates the body to burn fat by increasing muscle mass.

OBESITY

Obesity & Cardiovascular Disease

As discussed, ECE contains an optimal combination of natural compounds capable of suppressing triglyceride synthesis, while promoting cholesterol removal and cardiovascular protection. ECE provides additional cardiovascular protection for obese patients prone to CVD and CHD through lowering LDL cholesterol and scavenging free radicals.

DGAT Inhibition & Obesity

DGAT inhibition has recently been recognized as a novel and safe target for the treatment of obesity. DGAT is involved in intestinal fat absorption, lipoprotein assembly, regulation of plasma TG concentration, fat storage in adipocytes, and energy metabolism in muscle. DGAT knockout mice have been shown to have obesity resistance with a high-fat diet, the mechanism of which was confirmed to be through energy expenditure.

DIABETES

Aldose Reductase Inhibition

When blood sugar levels become elevated, aldose reductase is the enzyme that converts excess glucose into the sugar alcohol sorbitol. Sorbitol can build up in critical cells and cause damage. Recent research found that animals deficient in aldose reductase were protected from the retinal complications of diabetes. ECE compounds have been found to be potent aldose reductase inhibitors, which may be of benefit for patients with metabolic syndrome, syndrome X, or diabetes.

Reduced Fat in Liver & Pancreas

A mouse study showed that ECE reversed fat deposition in liver and pancreas cells. Furthermore, this same study showed that ECE served to markedly inhibit NF-kappaB inflammation in the pancreas. A recent Harvard (Joslin School of Diabetes) mouse study directly implicates excessive fat deposition in the mouse pancreas as turning on the NF-kappaB inflammation pathway, resulting in full-blown type II diabetes and insulin insensitivity in the mice.

SAFETY

ECE is manufactured from edible algae through food-compatible processes. Tens of thousands of people throughout the world have experienced ECE in various forms of product without side effects. To date, Dr. Lee’s team has not found any toxicity at any level. Several toxicity tests have been performed, and no adverse effects have been found at the effective human dose level of 1-10 mg/kg.

References:

  • “Composition For Prevention And Improvement Of Dementia And Promotion Of Memory, And Healthy Assistance Foodstuffs Containing The Composition” Korean Patent Application# 10-2003-88177 (Assigned To Haengwoo Lee).
  • “Compound For Improving Hypertension Containing Inhibitors Of Angiotensin Converting Enzyme Activity Extracted From Marin Plants And Articles Comprising Thereof”, Korean Patent Application 10-2004-24347 (Livechem, Inc).
  • “Compound For Improving Neuralgia Containing Dibenzo-P-Dioxine Derivatives Extracted From Marine Plants And Articles Comprising Thereof”.  Korean Patent Application 10-2004-0028066 (Livechem, Inc).
  • Ahn MJ, Yoon KD, Min SY, Lee JS, Kim JH, Kim TG, Kim SH, Kim NG, Huh H, Kim J. Inhibition of HIV-1 reverse transcriptase and protease by phlorotannins from the brown alga Ecklonia cava. Biol Pharm Bull. 2004 Apr;27(4):544-7.
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  • Becker AJ, Uckert S, Stief CG, Scheller F, Knapp WH, Hartmann U, Jonas U. Plasma levels of angiotensin II during different penile conditions in the cavernous and systemic blood of healthy men and patients with erectile dysfunction. Urology. 2001 Nov;58(5):805-10.
  • Becker AJ, Uckert S, Stief CG, Truss MC, Machtens S, Scheller F, Knapp WH, Hartmann U, Jonas U. Possible role of bradykinin and angiotensin II in the regulation of penile erection and detumescence. Urology. 2001 Jan;57(1):193-8.
  • Cases S, Smith SJ, Zheng YW, Myers HM, Lear SR, Sande E, Novak S, Collins C, Welch CB, Lusis AJ, Erickson SK, Farese RV Jr. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13018-23.
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  • Djukanovic, R., J.W. Wilson, K.M. Britten, S.J. Wilson, A.F. Walls, W.R. Roche, P.H. Howarth, S.T. Holgate.  1990.  Quantitation Of Mast Cells And Eosinophils In The Bronchial Mucosal Of Symptomatic Atopic Asthmatics And Healthy Control Subjects Using Immunohistochemistry.  Am.Rev.Respir.Dis. 142:863-871.
  • Dorrance AM, Lewis RW, Mills TM.  “Captopril Treatment Reverses Erectile Dysfunction In Male Stroke Prone Spontaneously Hypertensive Rats.”  Int J Impot Res. 2002 Dec;14(6):494-7
  • Fukuyama Y, Kodama M, Miura I, Kinzyo Z, Mori H, Nakayama Y, Takahashi M. Anti-plasmin inhibitor. VI. Structure of phlorofucofuroeckol A, a novel phlorotannin with both dibenzo-1,4-dioxin and dibenzofuran elements, from Ecklonia kurome Okamura. Chem Pharm Bull (Tokyo). 1990 Jan;38(1):133-5.
  • Fukuyama, Y., Kodama, M., Miura, I., Kinzyo, Z., Kido, M., Mori, H., Nakayama, Y., Takahashi, M. Structure Of An Anti-Plasmin Inhibitor, Eckol, Isolated From The Brown Alga Ecklonia Kurome Okamura And Inhibitory Activities Of Its Derivatives On Plasmin Inhibitors. Chem. Pharm. Bull. 37: 349-353 (1989)
  • Glombitza, K.W., Gerstberger, G. Phlorotannins With Dibenzodioxin Structural Elements From The Brown Alga Eisenia Arborea. Phytochemistry  24: 543-551 (1985)
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  • Hamed EA, Meki AR, Gaafar AA, Hamed SA. Role Of Some Vasoactive Mediators In Patients With Erectile Dysfunction: Their Relationship With Angiotensin-Converting Enzyme And Growth Hormone.  Int J Impot Res. 2003 Dec;15(6):418-25.
  • Henderson, W.R., E.Y. Chi. 1985.  Ultrastructural Characterization And Morphometric Analysis Of Human Eosinophil Degranulation.  J. Cell Sci. 73:33-48.
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  • Henderson, W.R., Jr., E.Y. Chi, C.R. Maliszewski.  2000.  Soluble Interleukin-4 Receptor (Sil-4R) Inhibits Airway Inflammation Following Allergen Challenge In A Mouse Model Of Asthma.  J. Immunol. 164:1086-1095.
  • Hoppe HA. (1979). Marine algae and their products and constituents in pharmacy. In: Marine Algae in Pharmaceutical Science. Hoppe HA, Levring T, Tanaka Y, eds. Berlin & New York: Walter de Gruyter.
  • Hoshino, M., Y. Nakamura, J.J. Sim.  1998.  Expression Of Growth Factors And Remodeling Of The Airway Wall In Bronchial Asthma.  Thorax 53:21-27.
  • Kang K, Park Y, Hwang HJ, Kim SH, Lee JG, Shin HC. Antioxidative properties of brown algae polyphenolics and their perspectives as chemopreventive agents against vascular risk factors. Arch Pharm Res. 2003 Apr;26(4):286-93.
  • Kang KA, Lee KH, Chae S, Koh YS, Yoo BS, Kim JH, Ham YM, Baik JS, Lee NH, Hyun JW. Triphlorethol-A from Ecklonia cava protects V79-4 lung fibroblast against hydrogen peroxide induced cell damage. Free Radic Res. 2005 Aug;39(8):883-92.
  • Kang KA, Lee KH, Chae S, Zhang R, Jung MS, Ham YM, Baik JS, Lee NH, Hyun JW. Cytoprotective effect of phloroglucinol on oxidative stress induced cell damage via catalase activation. J Cell Biochem. 2006 Feb 15;97(3):609-20.
  • Kang KA, Lee KH, Chae S, Zhang R, Jung MS, Lee Y, Kim SY, Kim HS, Joo HG, Park JW, Ham YM, Lee NH, Hyun JW. Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells. FEBS Lett. 2005 Nov 21;579(28):6295-304. Epub 2005 Oct 19.
  • Kang KA, Zhang R, Lee KH, Chae S, Kim BJ, Kwak YS, Park JW, Lee NH, Hyun JW. Protective effect of triphlorethol-A from Ecklonia cava against ionizing radiation in vitro. J Radiat Res (Tokyo). 2006 Mar;47(1):61-8.
  • Kang, K., Park, Y., Hwang, H. J., Kim, S. H., Lee, J. G., Shin, H.-C. (2003). Antioxidative Properties Of Brown Algae Polyphenolics And Their Perspectives As Chemopreventive Agents Against Vascular Risk Factors. Arch. Pharm. Res.. 26: 286-293
  • Kang, K.J., Hwang, H.J., Hong, D.H., Park, Y.J., Kim, S,H., Lee, B.H., Shin, H.C. Anti-Oxidant And Anti-Inflammatory Activities Of Ventol, A Phlorotannin-Rich Natural Agent Derived From Ecklonia Cava, And Its Effect On Proteoglycan Degradation In Cartilage Explant Culture.  Submitted To Molecular Pathology And Pharmacology
  • Kay, A.B.  1997.  T Cells As Orchestrators Of The Asthmatic Response.  Ciba Found. Symp. 206:56-67.
  • Kim MM, Ta QV, Mendis E, Rajapakse N, Jung WK, Byun HG, Jeon YJ, Kim SK. Phlorotannins in Ecklonia cava extract inhibit matrix metalloproteinase activity. Life Sci. 2006 Sep 5;79(15):1436-43. Epub 2006 May 7.
  • Krug, N., J. Madden, A.E. Redington, P. Lackie, R. Djukanovic, U. Schauer, S.T. Holgate, A.J. Frew, P.H. Howarth.  1996.  T-Cell Cytokine Profile Evaluated At The Single Cell Level In Bal And Blood In Allergic Asthma.  Am. J. Respir. Cell Mol. Biol. 14:319-326.
  • Lee, B.H., Stein, S. Improvement Of Learning Behavior Of Mice By An Antiacetylcholinesterase And Neuroprotective Agent Nx42, A Laminariales-Alga Extract. Presented To The Pharm. Soc. Kor., Spring Conference (2004); Manuscript Submitted To Korean Journal Of Food Science And Technology.
  • Lee, S.H., Han, S.B., Baik, J.Y. The Influence Of VNP Intake On The Symptoms Of Osteoarthritis Of The Knee Joint.  Clinical Report By Department Of Orthopedic Surgery, Anam Hospital, Korea University Medical Center
  • Mcever, R.P.  1991.  Selectins: Novel Receptors That Mediate Leukocyte Adhesion During Inflammation.  Thromb. Haemost. 65:223-228.
  • Myung CS, Shin HC, Bao HY, Yeo SJ, Lee BH, Kang JS. Improvement of memory by dieckol and phlorofucofuroeckol in ethanol-treated mice: possible involvement of the inhibition of acetylcholinesterase. Arch Pharm Res. 2005 Jun;28(6):691-8.
  • Nakamura, T., Nagayama, K., Uchida, K., Tanaka, R. Antioxidant Activity Of Phlorotannins Isolated From The Brown Alga Eisenia Bicyclis. Fisheries Sci. 62: 923-926 (1996).
  • Roche, W.R., R. Beasley, J.H. Williams, S.T. Holgate.  1989.  Subepithelial Fibrosis In The Bronchi Of Asthmatics.  Lance 1:520-524.
  • Ruehl ML, Orozco JA, Stoker MB, Mcdonagh PF, Coull BM, Ritter LS. Protective Effects Of Inhibiting Both Blood And Vascular Selectins After Stroke And Reperfusion. Neurol Res. 2002 Apr;24(3):226-32.
  • Sheehan, D.C., B.B. Hrapchak. 1980. Connective Tissue/Muscle Fiber Stains.  In Theory And Practice Of Histotechnology.  Battelle Press, Columbus, OH. 180-201.
  • Shibata, T., Fujimoto, K., Nagayama, K., Yamaguchi, K., Nakamura, T. Inhibitory Activity Of Brown Algal Phlorotannins Against Hyaluronidase. Int. J. Food Sci. Tech. 37: 703-709 (2002)
  • Shibata, T., Nagayama, K., Tanaka, R., Yamaguchi, K., Nakamura, T. Inhibitory Effects Of Brown Algal Phlorotannins On Secretory Phospholipase A2S, Lipoxygenases And Cycloxygenases. J. Appl. Phycol. 15: 61-66 (2003)
  • Shin HC, Hwang HJ, Kang KJ, Lee BH. An antioxidative and antiinflammatory agent for potential treatment of osteoarthritis from Ecklonia cava. Arch Pharm Res. 2006 Feb;29(2):165-71.
  • Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, Tow B, Sanan DA, Raber J, Eckel RH, Farese RV Jr. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat Genet. 2000 May;25(1):87-90.
  • Temann UA, Prasad B, Gallup MW, Basbaum C, Ho SB, Flavell RA, Rankin JA. A novel role for murine IL-4 in vivo: induction of MUC5AC gene expression and mucin hypersecretion. Am J Respir Cell Mol Biol. 1997 Apr;16(4):471-8.
  • Tsukada H, Nishiyama S, Fukumoto D, Ohba H, Sato K, Kakiuchi T. Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis. Synapse. 2004 Apr;52(1):1-10.
  • Uhm CS, Kim KB, Lim JH, Pee DH, Kim YH, Kim H, Eun BL, Tockgo YC. Effective treatment with fucoidin for perinatal hypoxic-ischemic encephalopathy in rats. Neurosci Lett. 2003 Dec 15;353(1):21-4.
  • Virag R, Floresco J, Richard C. Impairment Of Shear-Stress-Mediated Vasodilation Of Cavernous Arteries In Erectile Dysfunction.  Int J Impot Res. 2004 Jan;16(1):39-42
  • Wills-Karp, M., J. Luyimbazi, X. Xu, B. Schofield, T.Y. Neben, C.L. Karp, D.D. Donaldson.  1998.  Interleukin-13: Central Mediator Of Allergic Asthma. Science 282:2258-2261.
  • Zhu, Z., R.J. Homer, Z. Wang, Q. Chen, G.P. Geba, J. Wang, Y. Zhang, J.A. Elias.  1999.  Pulmonary Expression Of Interleukin-13 Causes Inflammation, Mucus Hypersecretion, Subepithelial Fibrosis, Physiologic Abnormalities, And Eotaxin Production.  J. Clin. Invest.

http://www.allergyresearchgroup.com/April-2007-Focus-Ecklonia-Cava-sp-28.html

February 9, 2008 Posted by | Anti-Aging, Antioxidants | , , , , , , , , , , , , , , , , , , , , | 20 Comments

Girls age three hitting puberty

By ALEX WEST

Published: Today

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http://www.thesun.co.uk/sol/homepage/news/article683176.ece

 

 

 

GIRLS are starting to hit puberty at the age of THREE.

Shocked doctors blame hormones in food and water for some British toddlers showing signs of breast growth.

Other pre-school youngsters even experience periods that normally start in their teens – and have temper tantrums just like adolescents.

The phenomenon is feared to have become more common since the 1990s – with doctors having to give increasing numbers of tots jabs to keep puberty at bay.

The mum of one girl, who at three was found to have the “bone age” of a nine-year-old, told how she was stunned when her daughter began acting like a ratty teen.

Hayley Holden said: “She used to slam doors and try and hit me. We’d go to supermarkets and she’d lie on the floor screaming.

“At the time, I just thought I had an ‘Omen’ child.”

She was stunned when medics told her Ellie-May – now eight – needed hormone injections to stave off puberty.

Harley Tedds, now ten, also has the painful jabs. Her mother Bernie said: “At five-years-old Harley was shaving her armpits and legs.

Bullied

“Her face and hands were appearing puffy – the nurse noticed she was developing breasts.”

Harley said: “I used to get bullied about how I look and I used to get dirty looks from people.

“You just want to be the same as your friends.”

Junk food diets could be another factor in the early onset of puberty, according to hormone expert Peter Clayton.

He said: “There might be a link between the increasing amounts of obesity in childhood and early puberty.”

The condition is examined on ITV1 at 8pm tonight in Teens Too Soon: A Tonight with Trevor McDonald Special.

a.west@the-sun.co.uk

 

January 14, 2008 Posted by | Health | , , | Leave a comment

Testing for Optimal Wellness

Testing for Optimal Wellness

Four Tests Lay the Foundation for An Effective Supplement Regimen

By Chris D. Meletis, ND

Individuals who want to make a stronger commitment to enhancing their health in 2008 as well as newcomers to the healthy aging supplement field, can dramatically improve the success of their regimen by first taking a series of tests. Beginning a supplement regimen without taking the tests mentioned below is a little like trying to navigate the streets of an unfamiliar city without a road map. I always tell my patients “Tests Don’t Guess.”

In this article, I will explain the different testing options available and how individuals can use the results to either build a new supplement program or refine an existing supplement regimen to enhance overall health.

Organic Acid Testing

One of the most underutilized tests, organic acid testing is a crucial step in determining exactly which vitamins and minerals a person’s body needs. Perhaps the reason why this test has been underutilized is simply because its relevance to personal health is not understood. Yet, it is one of the easiest ways to determine which supplements are right for each individual. It truly takes the guesswork out of creating the foundation for a personal customized supplement program. I tell my patients it provides a glimpse of their “own biochemical thumbprint.” Anyone who asks the questions “Where do I begin?” or “Now that I’m taking the basic supplements, what other nutrients do I need to improve my overall health?” will find the answers they’re looking for in the results of the organic acid testing.

We are all unique biochemical creatures. Therefore, each of us has different supplement needs. Some individuals may be deficient in vitamin E while others need extra coenzyme Q10, regardless of apparent cardiac issues or concerns. Everyone has inherent strengths and weaknesses within their personal biochemistry that determines how much of a particular nutrient—or even if that particular nutrient—will be of benefit to their bodies. Organic acid testing can help pinpoint the vitamin, mineral, and amino acid deficiencies present in each patient. The lack of proper nutritional sufficiency relative to your own “biochemical individuality” will play a pivotal role when it comes to expressing genetic strengths or weaknesses.

Organic acid tests are important for both those seeking to fine tune or increase a supplement program’s effectiveness and anyone beginning a supplement regimen. The clinical benefits seen when the body’s unique needs are addressed can be the difference between modest clinical results versus a significant metamorphosis.Testing_Figure1.gif

Organic acids are key compounds of many biochemical pathways. Organic acid testing provides critical insights into the functioning of the Krebs cycle in the mitochondria. The Krebs cycle is comprised of nine organic acids and eight enzymes and is the main way that all dietary fuel sources—including carbohydrates, proteins, and fats—are metabolized (Figure 1). Because the Krebs cycle provides the energy required for the body to function, any disruption in its flow can be disastrous to health.

Abnormal organic acid metabolism, therefore, can indicate that an individual is deficient in a number of nutrients or is simply not using those nutrients effectively.

Supplementation of specific vitamins and nutrients can help balance altered and imbalanced metabolic pathways, but it’s impossible to know which nutrients to give which patients unless an organic acid test is completed

Organic acid tests can now be done in the convenience of your home. Easily collected urine samples are sent to an internationally recognized and nationally certified laboratory. By taking this test, you can have a better understanding of your own unique health needs.1-5

Salivary Hormone Testing

Another important way to get serious about building a supplement regimen tailored to an individual’s own needs is salivary hormone testing.

There are several ways to test hormones (saliva, serum and urine), but the state-of-the-art testing is through saliva. This is because it measures only the active portions of hormones and it is these portions that determine how a patient feels.

The five hormones monitored through saliva testing are testosterone, progesterone, estrogen (estradiol), cortisol and DHEA. As we age, levels of these hormones often become imbalanced. Using a saliva test as a blueprint for proper supplementation with these hormones can make a dramatic difference in patients’ health.

Testosterone is important for both men and women. In males, the decline in testosterone commonly referred to as andropause often begins in the early 30s and eventually hits a crescendo when symptoms are unmistakable in the 50s and 60s. A progressive decline in testosterone in men starting at age 30 is well documented with a free testosterone decline of 1 percent per year. After age 60, 25 percent of men are clinically overtly hypogonadal (low in testosterone). Overt testosterone deficiency occurs in about 24 percent of men aged 50-60 years and 40 percent in men aged 60-80.6 Yet, subclinically, low testosterone levels are likely prevalent in nearly double these very conservative estimates. Furthermore, SHBG (sex hormone binding globulin) increases with age, binding up more free testosterone.

Low testosterone levels in men are linked to low energy, decreased libido, decreased concentration, insomnia, night sweats, depression, infertility and, surprisingly, even hot flashes.

Balanced testosterone levels are important in females as well, with lower than normal levels associated with a reduced sex drive.7 Testosterone is considered the “desire hormone” due to its ability to enhance libido. Women, however, often tend to have an excess of prolactin, the “anti-desire” hormone.8 In addition, with age, and especially after menopause, testosterone levels in women decline.7

Salivary hormone tests also are used to measure levels of estradiol, one of the main forms of estrogen found in the female body. Levels of this hormone drop dramatically during perimenopause and menopause and its deficiency is associated with vaginal dryness, hot flashes, and the many other symptoms of menopause. It is also thought that when estrogen levels plummet during menopause, it increases the risk of cardiovascular disease and high cholesterol. Excessively high estrogen levels, on the other hand, have been associated with an increased risk of breast cancer.

In males, estrogen levels are important to monitor since testosterone often can be converted into excess amounts of estrogen. Estrogen also tends to decrease testosterone production, creating a vicious circle.

Progesterone is another important hormone to have tested. During premenopause and menopause, the drop in progesterone levels is associated with estrogen dominance. Even before premenopause a progesterone deficiency can cause PMS, breast tenderness, and a host of other symptoms. Furthermore, groundbreaking work by Dr. John Lee noted that prostate problems in men can be associated with low progesterone levels.9

Cortisol and DHEA are important because of their role in adrenal health. Cortisol levels that are too low or too high can be a sign that a patient is suffering from adrenal exhaustion, a common cause of fatigue, weight gain and many other health problems. Imbalanced DHEA levels also can be a sign of exhausted adrenals. Like many other hormones, DHEA, which is associated with skin elasticity, well being, and cardiovascular health, drops dramatically with age. In some cases, however, individuals with impaired adrenals can produce excessive amounts.

Salivary testing can help a patient determine which hormonal supplements are needed to counteract any detected imbalances. Progesterone cream can be used in both females and males who test low for this important hormone. BioDIM® and Extension Resveratrol can be used in males who are converting testosterone into excess estrogen. Adaptogens and special cortisol-lowering herbs known as Relora® and Sensoril™ can be used in individuals with adrenal dysfunction while DHEA supplementation can be used to replenish the body’s low supplies of this hormone. Women who have lower than normal testosterone levels can use DHEA to raise testosterone levels, since women very efficiently convert DHEA to testosterone. Many males with low testosterone find it helpful to either increase their levels pharmaceutically or use a combination of the botanicals Eurycoma longifolia jack extract, stinging nettle, and Luteolin. Finally, women with low estrogen levels can seek out bio-identical hormone replacement (BHRT).

Retesting after initiating a hormonal support regimen ensures that individuals have achieved the proper hormonal balance and that excess estrogen levels are not created as a result of therapy.

Food Allergy Testing

Clinically, one of the most important tools I use to unearth hidden factors affecting patients’ health is Food Allergy Testing. This approach ensures that individuals can understand how their daily diet may be harming their health.

Food allergens can be broken down into two categories: immediate and delayed. It is the delayed or hidden food allergens that silently erode away ones health, frequently going undetected since the response is not immediate but rather delayed up to 72 hours, long after the offending food(s) were ingested. Thus, identifying and controlling food sensitivities is essential.

Hippocrates “The Father of Western Medicine” stated in 400 BC, “May Food be your Medicine and Medicine be your Food.” The problem that I discover with my patients is that even supposedly healthy foods such as garlic, broccoli, grapes, and fish can be sources of extremely detrimental health signs and symptoms.

ELISA immunoassay testing for delayed food allergies helps identify delayed IgG immunoglobulin allergens. This technology is used worldwide and has now been applied to home test kits that can identify 96 different food reactions ranging from dairy, wheat, corn, fish, vegetables, fruits, sugar cane, numerous nuts, eggs and other commonly consumed foods. A simple fingerstick done at home, much like that done by diabetics, makes gaining insight into ones own personal delayed food allergies both affordable and convenient. Once collected, the sample is sent from the home to a CLIA (nationally licensed) laboratory. Within a couple of weeks, results are sent back directly to the patient’s home. These results indicate low, moderate or high reactions to different foods.

The food allergy test will help individuals avoid the foods they are allergic to and will produce dramatic results in improving overall health. After understanding ones food sensitivities, Digestive Enzymes, a good probiotic supplement that includes Lactobacillus GG and Lectin Lock™ can be added to a supplement regimen to compensate for those times when people are exposed to their most common food allergens.

Anyone who is on immunosuppressant drugs, such as corticosteroids, should be aware that these drugs can alter the results of food allergy testing.

Iodine Sufficiency Test

Thyroid disorders are becoming almost epidemic in this country. Hypothyroidism is one of the most common disorders I see in my patients, who often don’t realize that their weight gain, moodiness, thinning hair and other symptoms are caused by hypothyroidism.

Noted iodine expert Dr. Guy Abraham has established a link between iodine deficiency and both hypothyroidism and hyperthyroidism. Because so many dietary components—such as the bromide found in bread and baked goods and fluoride in drinking water—compete with iodine absorption, iodine deficiency has become all too common.10

A user-friendly, oral loading test can detect iodine deficiencies. Testing involves collecting urine immediately upon arising in the morning to use in what’s called a spot test. Then, 50 mg. of potassium iodide and iodine (included in the test kit) is ingested. Urine is collected throughout the day until the first urine of the next morning. The samples, including the baseline spot test, are shipped to the lab.

If the body has sufficient iodine, at least 90 percent will be excreted in the urine. In iodine deficiency, however, the body will hold on to some of the iodine to compensate for the deficiency. The more iodine that remains in the body, the more a person is iodine deficient and needs to begin supplementation.

If the tests indicate an iodine deficiency, patients often begin supplementing with iodine, such as found in Iodoral®, a combination of iodide and iodine. Testing should be repeated every three to four months to monitor proper iodine doses. Working closely with your personal healthcare provider is always an important part of refining your health program.

Conclusion

Organic acid, salivary hormone, food allergy, and iodine sufficiency testing are the best way to build a supplement program that is specific for an individual’s needs. In my practice, I have noted dramatic improvement in the overall quality of my patients’ health after they have begun a supplement regimen based on these tests. Not using this important tool is like stumbling around in the dark when all one needs to do is turn on the flashlight that’s already in his or her hand. For individuals who want to get serious about overall wellness in 2008, taking each of these tests is a crucial step toward good health.

References

1. Fu X, Iga M, Kimura M, Yamaguchi S. Simplified screening for organic academia using GC/MS and dried urine filter paper: a study on neonatal mass screening. Early Human Development. 2000;58:41-55.

2. Fu X, Kimura A, Iga M, Yamaguchi S. Gas chromatographicmass spectrometric screening for organic acidemias using dried filter paper: determination of alpha-ketoacids. J Chromatography B Biomed Science Applications. 2001;758:87-94.

3. Greter J, Jacobson C. Urinary organic acids: isolation and quantification for routine metabolic screening. Clin. Chem. 1987;33:473-480.

4. Sweetman L. Organic acid analysis. Techniques in diagnostic human biochemical genetics. A laboratory manual. Wiley- Liss, New York, 1991.

5. Tanaka K, et al. Gas chromatographic method of analysis for urinary organic acids. I. retention indices of 155 metabolically important compounds. Clin. Chem. 1980;26:1839-1846.

6. Morgentaler A, Bruning CO 3rd, DeWolf WC. Occult prostate cancer in men with low serum testosterone levels. JAMA. 1996 Dec 18;276(23):1904-1906.

7. Kingsberg S, Shifren J, Wekselman K, Rodenberg C, Koochaki P, Derogatis L. Evaluation of the clinical relevance of benefits associated with transdermal testosterone treatment in postmenopausal women with hypoactive sexual desire disorder. J Sex Med. 2007 Jul;4(4 Pt 1):1001-8.

8. Hirch E. [Libido disorders] [Article in French]. Rev Med Brux. 2007 Sep;28(4):368-73.

9. Lee, J. Prostate disease and hormones. The John R. Lee, M.D. Medical Letter Feb. 2002.

10. Abraham G. Iodine: The Universal Nutrient. Vitamin Research News. October 2005.

http://www.vrp.com

What is the Organic Acid Test?

Sample of the Organic Acid Test (In order to be able to view the test sample, you must have the FREE Adobe Reader installed. To Download and install now, please click here)

In which conditions is the test useful?

How Much Does the Organic Acid Test Cost?

Treatment Options

Benefits of the Organic Acid Test

Frequently Asked Questions About The Organic Acid Test

Diagnostic Uses of Organic Acid Testing

Organic Acid Metabolites

Order the Organic Acid Test

What is the Organic Acid Test?

Selective immunodeficiency, exposure to broad-spectrum antibiotics, and consumption of sugars, individually or in combination, can stimulate an overgrowth of intestinal yeast or bacteria, normally present in much lower quantities. Once any abnormalities are detected there are a variety of treatment options. Improvements that have been reported to us during and after treatment include better eye contact, improved language, less self-abusive behavior, less hyperactivity, better sleeping habits and less stimming. These organisms and their metabolites can produce or exacerbate symptoms in many conditions.

The organic acid test evaluates all of the well-defined inborn errors of metabolism that can be detected with this technology (called GC/MS) such as PKU, maple-syrup urine disease, and many others. In addition, we check for many other abnormalities such as vitamin deficiencies and abnormal metabolism of catecholamines, dopamine, and serotonin. We currently quantitate 65 substances, but also evaluate other substances that are not quantitated. Some of the other biochemical abnormalities common in autism include elevated uracil and elevated glutaric acid.

Panel Includes:

  • Yeast metabolites
  • Bacteria metabolites
  • Nutritional deficiencies
  • Antioxidant deficiencies
  • Inborn errors of metabolism
  • Amino acid abnormalities
  • Fatty acid abnormalities
  • Exposure to solvent toxins
  • Deficiencies of B vitamins or vitamin C
  • Neurotransmitters
  • Indications of diabetic conditions
  • Krebs cycle metabolites
  • Clostridia overgrowth
  • Glycolysis
  • Pyrimidines
  • 65 important compounds

(See Detailed Listing.)

 

In which conditions is the test useful?

AD(H)D Chronic Fatigue Syndrome Endometriosis

 

How Much Does the Organic Acid Test Cost?

The test kit is free; please see our price list for current processing charges including courier charges (for US residents) and a full report, along with professional consultation concerning test results.

Other questions about cost are answered in our Testing FAQ and Insurance & Payment Information.


Treatment Options

Depending on test results, suggestions can include:

  • Diet modification
  • Diet supplementation, primarily with nutrients which increase the quantity of beneficial bacteria (e.g. lactobaccilli) in the GI tract
  • Oral antifungal or antibacterial (anaerobic) medications
  • Vitamins and Antioxidants
  • Reduction of exposure to toxic chemicals


Benefits of the Organic Acid Test

  • Measures 65 important compounds for overall health
  • Focuses on detecting yeast and bacteria byproducts that have been implicated in many disorders
  • Requires a first morning urine sample only
  • Consultation on results is included with each test from The Great Plains Laboratory
  • Test with the experts – The Great Plains Laboratory holds one patent (*) on this test and two others pending.

* Certain uses of the compounds arabinose, citramalic, tartaric, 3-oxoglutaric, carboxycitric, 3,4-dihydroxyphenylpropionic acid, and 3-(3-hydroxyphenyl)-3-hydroxypropionic acid in their application to autism in the organic acid test and microbial organic acid test are protected by USA patent 5,686,311 granted November 11, 1997.

 


Frequently Asked Questions About The Organic Acid Test

What is the organic acid test for, and how can it help?

In Dr. Shaw’s work, he noticed that people with autism and other conditions (such as attention deficit disorder and fibromyalgia) frequently had overgrowths of yeast and bacteria in the gastrointestinal tract, due to a high-sugar diet and antibiotic overuse. This led Dr. Shaw, now Director of The Great Plains laboratory, to devise a urine test to detect such disorders–an organic acid test which measures nearly 70 different biochemical compounds.

Both children and adults who have taken the test and sought appropriate treatments have enjoyed marked improvements in condition as a result.


Do I have to obtain a physician’s approval to get the urine sample tested?

Yes. A medical practitioner who is licensed to order urine testing in your state must approve the test order. Regulations vary from state to state so an approved medical practitioner could be a medical doctor (MD), osteopath (DO), nurse practitioner, chiropractor (DC) or naturopath (ND).


Why should I get the organic acid test? Why don’t I just start the antifungal treatment?

Some children with autism don’t have the yeast problem, but have an overgrowth of the Clostridia. Treating these children with an antifungal could make the bacteria problem even worse. Also, if your child has the yeast problem, it will likely require major changes in diet (for the child and the family) along with drug therapy for six months or longer. It will be very difficult to make this type of commitment if you are nor even sure if your child has the yeast problem.

Also, your child could have a yeast overgrowth with a drug-resistant yeast and if you don’t do the testing beforehand, it would be difficult to know what was happening. If the problem is severe, the yeast die-off reaction may be more severe and you may want to take additional steps to control the yeast before using antifungals. Additionally, it may be very difficult to get your doctor’s cooperation for the prescriptions and insurance reimbursement if there is no evidence that the yeast problem even exists.


How often should I get my child retested?

As a general rule, every three months is satisfactory. However, retesting should be done sooner if the child does not respond favorably by the end of one month of antifungal therapy, since the yeast or bacteria might be resistant to the drugs used for treatment.


My child is currently taking antibiotics now. Should I wait until after antibiotics treatment until I get tested?

An assumption is frequently made that if the child has a significant yeast overgrowth of the intestine while on antibiotics, the yeast overgrowth will disappear when the antibiotics are stopped.

However, this is not necessarily the case and the yeast overgrowth may even become worse–especially if the person is on a high-sugar, high carbohydrate diet. There is no evidence that the yeast overgrowth will spontaneously disappear. Furthermore, the yeast overgrowth may be suppressing the immune system, preventing your child from recovering from the infection.

The sooner the yeast problem is controlled, the sooner the vicious cycle of antibiotics and frequent infections will be broken.


Will drugs or nutritional supplements interfere in the organic acid test?

No, there is no interference from any known drug or supplement. However, if antifungal supplements or drugs are taken before the test, you will probably get a lower value for the yeast byproducts. We advise you to get the test first so that you will know what the starting point is.


I already had the urine organic acid test done earlier by another lab. Can’t I get the information from the earlier test?

No. No other laboratory routinely analyzes the same compounds as this laboratory. Most test for the inborn errors of metabolism and nothing more.


I have an HMO and they have to send the test to a certain lab. Is that OK?

No. No other laboratory routinely analyzes the same compounds as this laboratory (including Labcorp, SmithKline, or Mayo Medical laboratories).

If you do not specify our laboratory, your child’s urine will be sent to one of the large reference labs which cannot accurately evaluate your child’s condition. Most test for the inborn errors of metabolism and that’s all.


Are there any other reasons that I should choose the Great Plains Lab to do the organic acid testing?

Dr. William Shaw, Director of the Great Plains Laboratory, is a recognized expert in the identification of practical, biomedical treatments for autism (as well as many other disorders). His work and the testing procedure that he developed have helped many children and adults with autism and other conditions see dramatic improvements and experience an enhanced quality of life–all based on seeking appropriate therapies using the information gained from the test.

Dr. Shaw has also authored many books and provided other materials to help you better understand the medical treatments and how to use this information to help people with autism and other conditions.

http://www.greatplainslaboratory.com/Organic-Acid-Test.html

December 18, 2007 Posted by | Anti-Aging, Autism, Health | , , , , | Leave a comment

SCIENTIFIC TERRORISM

SCIENTIFIC TERRORISM


by Scott Tips, JD
December 2, 2007
NewsWithViews.com

I was recently struck by a thought that in this new “Age of Terrorism” we – you and I – have been subjected to a form of terrorism that can best be described as “scientific terrorism.”

Of course, if a terrorist pulls a gun on innocent people and shoots them, or blows himself up in a crowded area and takes innocent lives, then he has clearly committed a terrorist act. The definition of terrorism itself is, I know, at once vaguer and more involved than that; however, it is enough for my purpose here to describe it in this way because such terrorists will have, if successful, deprived those individuals of their health and even lives.

With Diplomas, Not Guns

Consider, then, those persons who don’t use guns but instead diplomas, impressive titles, and computers to deprive us of our health and even our lives. For most people, these kinds of terrorists are hard to spot. They often wear suits and ties, sport enough degrees after their names to choke an elephant, and speak in serious and seemingly knowledgeable tones about science and health. And they can kill you just as dead as any trigger-happy terrorist hefting a box-cutter or an AK-47.

So where do we find these scientific terrorists? Unfortunately, they usually occupy positions of power and authority – in the medical community, in universities, and in government circles. And from these lofty bastions of dominion, they issue pronouncements that they expect most people to believe and act upon, starry-eyed and without looking beyond the superficial credentials and appearances. Regrettably, most people do.

For years, these Scientific Terrorists have been telling you:

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    To take drugs when they are either unnecessary or contraindicated;

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    To undergo surgery when either unnecessary or contraindicated;

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    To undergo radiation treatment when either unnecessary or contraindicated;

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    To undergo hospitalization when either unnecessary or contraindicated;

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    That pesticide and herbicide residues in your foods will not hurt you or your children;

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    That vitamin-and-mineral supplements are a waste of money and result in nothing more than expensive urine;

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    That organic and whole foods are unnecessary and a waste of money;

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    That expensive and costly regulations are necessary to protect your health; and

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    That you are incapable of making “complicated” health and safety decisions affecting you and your family’s health, which decisions are better left in the hands of the educated elite.

 

The Butcher’s Bill

But, as we know, these experts – who are supposedly so smart and capable – almost always get “it” wrong. And, worse, when they get it wrong, they do a spectacular job of it too. Although the data varies depending upon the source, just look at what the butcher’s bill comes to:

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    106,000 deaths annually, at a cost of $12 billion, from adverse drug reactions;

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    98,000 deaths annually, at a cost of $2 billion, from medical errors;

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    115,000 deaths annually, at a cost of $55 billion, from bedsores;

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    88,000 deaths annually from infections, at a cost of $5 billion, caused by medical intervention;

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    37,000 deaths annually, at a cost of $122 billion, from unnecessary medical procedures;

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    32,000 deaths annually, at a cost of $9 billion, from surgery-related medical intervention

 

The above figures do not include those outpatient deaths from medical intervention (some 199,000 annually at a cost of $77 billion), or the astounding figures from Dr. Lucien Leape’s 1997 study of medical and drug-error rates (3 million deaths annually, he reports!) (Leape LL, “Error in Medicine,” JAMA, 1994 Dec 21;272(23):1851-7).

On the more conservative end of the spectrum, even an expert panel from the Institute of Medicine (of the National Academy of Sciences) found that medical errors kill from 44,000 to 98,000 Americans each year. (British Medical Journal, 1999 December 11; 319(7224): 1519.

Medical errors in the United States alone cause more deaths annually than car crashes, AIDS, or breast and prostate cancer. This is equal to a 300-person jumbo jet crashing every single day of the year, day after day after day.

And They Are Still At It

These terrorists, though, are not just content with subjecting us to their brand of medieval medicine. They also seemingly want to make sure that we are vulnerable to diseases and medical problems, which in turn will require increased use of their medicines and hospitals. Why do I say this? Because every time that any of us use effective preventative measures to protect ourselves, they try to suppress them – through the media, through doctors, and, above all, through their coercive enforcement tool – the government.

And what are examples of this? Just consider the attempts of some “institutions” to limit the potency of dietary supplements, which are scientifically-proven disease preventatives. At the Codex level and in the European Union, the German Risk Assessment Institute (BfR) has put forth what it considers to be the maximum permitted upper levels of safe consumption of vitamin-and-mineral supplements. They caution, for instance, that no niacin supplements above 17 milligrams should be sold to consumers. Nor should Vitamin C tablets exceed 225 milligrams. For mineral supplements the BfR is equally strict: zinc tablets should not exceed 10 milligrams, nor should selenium capsules go above 70 milligrams each.

Given the overwhelming amount of evidence that exists showing not only the safety of such supplements but their efficacy, there can only be two reasons why they are trying to suppress these alternative means: Either they are (1) completely clueless, or (2) they are trying to keep us sick, or worse, kill us.

Of course, there are well-intentioned individuals in every such group. But for those who are engaging in these activities knowingly and with, as they say in law school, deliberate aforethought, these persons are terrorists in every sense of the word. And there is a very special place in hell reserved for them, I’m sure.

Fortunately, there are many of us working together to stop this form of scientific terrorism. The National Health Federation has been on its own anti-terrorist mission for years now throughout the World, but especially in the United States and at Codex. They may have the advantage of more money, but we have the advantage of something more important: We actually fight for Freedom, and for Life itself.

To better understand the Codex Alimentarius Commission and the global food standards and guidelines that it is creating, you must read Codex Alimentarius – Global Food Imperialism. This book is a collection of articles by those few health-freedom activists with first-hand knowledge of Codex and the dangers that it poses to our health and health freedom. Compiled by Scott Tips, this easy-to-read book can be purchased here.

 

 

 

 

 

 

 

 

 

© 2007 – Scott Tips – All Rights Reserved

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Scott Tips received his Bachelor of Arts degree, magna cum laude, from the University of California at Los Angeles in 1976, studied at the Sorbonne (Paris I) from 1976-1977, and obtained his Juris Doctorate degree from the University of California, Berkeley School of Law (Boalt Hall) in 1980, where he was the Managing Editor of the California Law Review. A California-licensed attorney, he has specialized in food-and-drug law and trademark law, but also engages in business litigation, general business law, and nonprofit organizations, with an international clientele.

Since 1989, Mr. Tips has been the General Counsel for the National Health Federation, the World’s oldest health-freedom organization for consumers, and is now its president. He also writes a regular column for NewsWithViews.com and Whole Foods Magazine called Legal Tips, a column he started in 1984. Currently, Mr. Tips is occupying much of his time with health-freedom issues involving the Codex Alimentarius Commission and its and other attempts to limit individual freedom of choice in health matters.

To understand better the Codex Alimentarius Commission and the global food standards and guidelines that it is creating, you must read Codex Alimentarius – Global Food Imperialism. This book is a collection of articles by those few health-freedom activists with first-hand knowledge of Codex and the dangers that it poses to our health and health freedom. Compiled by Scott Tips, this easy-to-read book can be purchased here.

Website: National Health Federation

E-Mail: sct@thenhf.com

http://www.newswithviews.com/Tips/scott.htm

December 18, 2007 Posted by | Health | , , , , , | Leave a comment

Why Doctors are Idiots: 150 Years of Disatrous Advice on Children’s Health (satire)

Why Doctors are Idiots: 150 Years of Disatrous Advice on Children’s Health (satire)

With mandatory vaccines suddenly being forced onto parents by doctors and so-called “health authorities” in places like Maryland, New Jersey and Texas, you might think that doctors being full of bunk is a new phenomenon. But no, it’s nothing new. Doctors have been full of bunk for more than a hundred years! What follows is a short timeline of the nonsense, junk science, negligence and harmful advice peddled by medical doctors over the last 150 years or so: (see the end of this article for serious follow-up comments describing the intent behind this satire piece)

1850’s

Ignaz Semmelweis, an Austrian-Hungarian obstetrician working in a clinic that delivers babies, is labeled “insane” by his fellow doctors for having the audacity to suggest that doctors should wash their hands between delivering babies. He’s fired from his job, ostracized by the medical community and later dies in an insane asylum and is only vindicated long after his death when it is realized that, indeed, infections are spread from one patient to another by physicians who are too lazy, stubborn or egoistic to simply wash their hands. (A lack of hand washing continues to be the primary reason why MRSA and other superbugs are spread in hospitals today…)

1920’s

Don’t breastfeed your babies! Use infant formula instead. It’s more “high-tech.” Cow’s milk is obviously healthier for your babies than mother’s milk, right? That’s what the doc says… Result: Tens of millions of mothers stopped breastfeeding their babies, resulting in widespread nutritional deficiencies that impacted those children for life. The pushing of infant formula onto mothers continues today in hospitals across the country which are paid by infant formula manufacturers to give free samples of infant formula to new mothers, hoping they will stop breastfeeding and start buying formula. (Saving grace: A few courageous pediatricians now speak out forcefully about the importance of breastfeeding…)

1930’s

Smoking while pregnant? No problem. Doctors recommend Camels more than any other cigarette! Result: Massive chemical toxicity of the bodies of newborns. Increased cancer risk, reduced brain development and a lifetime of immune system disorders. (Cigarette ads routinely appeared in the Journal of the American Medical Association for well over a decade.)

1940’s

Need a new pair of shoes for your kid? Go size ’em up with the fluoroscope X-ray machine at your local shoe store! Never mind the radiation exposure of 20 – 75 rems per minute! See wikipedia article here. Result: Massive increase in cancer among parents and children who visited the shoe stores. Doctors remained silent on this significant health risk for decades while millions were harmed — even after strong evidence pointed to the fact that X-ray radiation caused cancer.

1950’s

Hey pregnant women, take thalidomide for your cancer! Don’t worry about your unborn children. This chemical is perfectly safe! Result: 10,000 children born with physical deformities. Doctors continued to use infants and pregnant women in pharmaceutical experiments for the next fifty years. See Vaccines and Medical Experiments on Children, Minorities, Woman and Inmates (1845 – 2007).

1960’s

Feed your children processed foods! White bread is good for them, don’t you know? And monosodium glutamate is perfectly healthy for children, which is why food companies add it to baby food! So is saccharin, hydrogenated oils and sodium nitrite in processed meat. Result: Massive malnutrition, liver damage, and the beginnings of the diabetes and obesity epidemics that would sweep the nation over the next generation.

1970’s

Place mercury into the mouths of your little children by having their cavities filled with “silver” fillings (made with 40% mercury, a potent neurotoxin). Result: Widespread mercury toxicity in children, resulting in a sharp increase in neurological conditions, including behavioral disorders, infertility and autism. Ignorant, obstinate dentists continue to use mercury fillings today, and the American Dental Association remains in full support of this extremely dangerous heavy metal that results in the mass poisoning of children.

Your kid have a cold? It’s probably because their tonsils need to be removed! Tonsils have no biological function anyway, doctors claimed. Result: Over the last several decades, surgeons have removed tens of millions of tonsils, maiming children with a medically useless procedure that has now been proven virtually worthless. But it sure did raise funds to pay for the luxury German sedans driven by those surgeons!

1980’s

Microwave all the food you feed children. It’s quick, convenient and perfectly healthy! Result: A massive increase in the consumption of processed, artificially modified and dead foods. The introduction of the microwave correlates nearly perfectly with the explosion of obesity and diabetes in western nations. Most doctors still have nothing negative to say about the use of the microwave.

Does your child have an ear infection? Hammer them with antibiotics. Don’t worry about the fact that antibiotics are useless against ear infections, or that they wipe out your child’s friendly intestinal flora and cause nutritional deficiencies. It’s doctor-recommended, so it must be good, right? Result: Billions of doses of useless antibiotics helped breed a new generation of superbug viruses that have now escaped the hospitals and are infecting the public at large. Antibiotics are useless to stop them, and doctors still have not figured out that you can kill superbugs with colloidal silver or garlic. (A fact that ancient human civilizations knew thousands of years ago…)

1990’s

Coat your children with sunscreen. The sun is dangerous and has no health benefits whatsoever, didn’t you know? And besides, all those chemicals in sunscreen are perfectly safe. Result: Children are now living with severe vitamin D deficiencies (even rickets!) that greatly increase rates of breast cancer, prostate cancer, osteoporosis, depression, obesity and diabetes. Doctors still don’t recognize the important role of vitamin D in children’s health, and they prescribe drugs to treat the symptoms of disease rather than recommending vitamin D (which would correct the underlying problems and eliminate the need for pharmaceuticals).

Does your baby have a cough? Feed ’em sugared-up, chemically-contaminated cough syrup made by pharmaceutical companies. Don’t worry that it’s never been tested on infants or approved by the FDA. It works, right? It’s doctor-recommended! Result: Over a billion doses of useless, “quack” cough medicine swallowed by infants. The cough syrup hoax was finally blown wide open in 2007 when a few courageous pediatric physicians finally admitted the products have absolutely no medicinal effects and might, in fact, be dangerous for infants and children. The FDA continues to allow their sale, however, since they’re still quite profitable to Big Pharma (even though they don’t work).

Is little Johnny a bit too jazzed up for your comfort level? Don’t worry, psychiatrists have a solution: Street drugs for children! Illegal amphetamines are now legal thanks to the Big Pharma / FDA partnership, and your friendly psych doctor is ready to prescribe Ritalin and antidepressant drugs to your “hyperactive” kids. Result: Widespread school shootings in America. Tens of millions of children suffer stunted physical and mental development — a dangerous side effects that doesn’t emerge until 2007. See http://www.newstarget.com/021944.html

2000’s

Too posh to push? Don’t worry, your obstetrician will schedule a C-section childbirth appointment and deliver the baby on YOUR schedule instead of Mother Nature’s. It’s more convenient for him, too, because then he can still make his golf game. Don’t worry about the baby: There’s no benefit to vaginal childbirth anyway, right? What better way to welcome your child to the world than with a scalpel! Result: Millions of women subject their children to non-natural child birthing that results in an increased risk of lung disease afflictions as well as psychological birthing trauma lasting a lifetime.

Worried about your child getting an infectious disease? Inject your children with multiple vaccines. It will protect them from infectious disease and may, in fact, protect them from oral sex! (At least that’s what Merck claims.) Besides, there’s nothing wrong with a little mercury, right? Result: Unknown. It’s a great medical experiment now being conducted on the children of America. It’s backed by idiot doctors and gun-toting law enforcement personnel who are ready to arrest parents who resist the vaccination mandates.

Need some food for your baby? Buy Similac (or any other baby formula powder). It’s made with 42.6% corn syrup solids and 10.1% sugar, making it over 50% refined sugars! Marketed with a cuddly teddy bear on the front label and sporting the claim, “Balanced nutrition for older babies,” Similac and other infant formula products are little more than sugar water for babies. Doctors and pediatricians remain silent. There is no outcry. No national scandal. No action by the FDA to protect babies. Some doctors even recommend this stuff! (And stupid parents keep buying it!)

2007

A survey of 1,600 practicing physicians published in the Annals of Internal Medicine reveals that reveals that nearly half of all doctors failed to report an incompetent colleague who posed a risk to the health or safety of a patient. The same survey also revealed that a majority of doctors would send their patients to get expensive imaging work done at an imaging facility in which they held a financial interest, but only 24 percent of doctors said they would reveal that conflict of interest to patients.

Result: Yet more incompetent, dishonest doctors continue to scam customers and harm patients. The scourge of modern medicine continues as corrupt, ignorant and downright incompetent doctors continue to harm millions of expectant mothers, infants, babies and children with their deadly Big Pharma chemicals and disastrous health advice. The reputation of doctors plummets in the minds of the American public, and most patients now turn to the Internet to find answers that their doctors either don’t know or refuse to tell them. The mass exodus of patients away from conventional medicine is now well underway…

Why doctors are still idiots

When it comes to medical idiocy, these examples are just the tip of the iceberg. The same hopelessly outdated medical system that has given us cigarette-promoting doctors, breastfeeding-censoring doctors and superbug-breeding doctors is now claiming your children need yet more chemicals in their bodies in the form of vaccinations!

And, by the way, these doctors are the only people in the world who are right. They’ll tell you so themselves! They are the sole source of all knowledge on anything related to health and medicine, and they’ve now garnered enough political power that they’ve managed to criminalize parents who disagree with their medical dogma.

You know what the difference is between God and doctors?

God doesn’t think he’s a doctor.

These days, instead of doctors simply being full of nonsense, they are suddenly a very real danger to your personal freedom. Before, they were just peddling health nonsense. Now they hold the keys to your freedom and the custody of your children. Refuse to go along with new mandatory vaccination programs in New Jersey, for example, and you can be arrested, imprisoned, charged with a crime and have your children kidnapped by Child Protective Services. How dare you disagree with the High Priests of medical dogma!


Personally, I don’t necessarily mind doctors being full of crap. It’s amusing to watch, and hilarious to document_ But I do mind doctors being full of crap while invoking law enforcement authorities to pull out a Glock, slap a 10-round magazine in the grip, point the barrel to the head of a mother of three children and demand, “Take OUR medicine, or you’ll be arrested.” Which is, of course, essentially what’s happening in New Jersey and Maryland right now. It’s called Gunpoint Medicine, and if you don’t believe me, move to New Jersey, and refuse to have your children vaccinated. It won’t be long before armed men show up at your front door with Child Protective Services standing behind them, ready to grab your kid, toss him into an unmarked van, and have you arrested for “resisting vaccination.” This is not fiction. I couldn’t make this stuff up if I tried. It takes truly evil people to dream up this kind of medical terrorism — the very people who work for Big Pharma and the FDA.

Or maybe I’m wrong about all this. Maybe doctors and health authorities have been full of crap for a hundred years, and now all of a sudden in 2007, they’re instantly right! Maybe they’ve been visited by supernatural, omniscient beings who gave them perfect knowledge (along with a new Merck vaccine) and all they’re doing is running around the country saving little children’s lives for the good of humanity.

Perhaps 2007 is the new Golden Age of children’s health, to be initiated with a mass injection of kiddies with a dozen new toxic mercury injections to “protect” these kids from things that will probably never happen to them. Maybe now, in 2007, organized medicine has reversed all its years of bullsnot and finally found the light! And that light, we’re told, comes in the form of a pill… or a vaccine… or chemotherapy… or whatever they tell you to take next.

Yes, indeed! We’ve been saved by Big Pharma and a brigade of doctors! Hail the FDA! Praise the pharmaceutical giants! Give thanks for mandatory injections! Listen to the doctors and we’ll all be saved!

Quick Note: This satire piece does not mean to imply that ALL doctors are complete idiots when it comes to health. There are exceptions. Many of the outstanding people I know in natural health started as conventional medical doctors (M.D.s). The difference between complete idiot doctors and intelligent doctors is that idiots are not willing to abandon their existing dogmatic beliefs when faced with new, contradictory evidence. Intelligent people, on the other hand, adapt and evolve their ideas when faced with new information or evidence.

Conventional medicine, for the most part, does not want to learn anything new that might challenge its existing status quo dominance over the lives of parents and children. “Innovation is the enemy of the status quo,” and genuine health enhancement (and disease prevention) is the enemy of the entrenched medical industrial complex. Most doctors are complete idiots because they follow a dogmatic, religious-like belief in blatantly outdated junk medical science, even when real world observations and evidence demands the embracing of ideas that overthrow previously protected beliefs and career egos.

Until doctors can abandon their egos and admit they don’t know everything, they will continue to be full of crap.

The purpose behind this satire piece is not to engage in silly name-calling exercises, but rather to play an important role in social commentary on the huge failures of modern medicine today. Satire and humor have important functions in any free society: They reveal what’s wrong in a hilarious light, simultaneously entertaining us while encouraging us to challenge our own ideas and, perhaps, come up with new, better solutions for future generations. Political cartoons, stand-up comedians and satire pieces like this one all play a role in getting people to think more carefully about the issues at hand.

Consider this: If modern medicine really worked well, and if doctors were creating wonderful solutions that kept people healthy, then we wouldn’t have much of anything to make fun of! The fact that silly humor and examples of idiotic behavior are so easy to find in conventional medicine today is indicative of the failure of medicine to be effective. Satire “attack” humor carries a sub-text message that says, “We can do better.” We don’t have to suffer under an idiotic system of medicine. We can create a better future based on genuine health freedom, the promotion of disease prevention programs, and the embracing of plant-based medicines that are safe, affordable and highly effective.

Until we get there, poking fun at the hilarious (but sometimes quite harmful and disastrous) failures of conventional medicine is an important way to keep reminding us all how crazy we are to follow this entrenched system of failed medicine. After all, if conventional medicine really worked well, wouldn’t we all be healthy by now?

Finally, I must add that there is idiocy and humor in every industry. Even natural health has its own idiots, too. Every industry has some area that can be improved, and there are always idiots working alongside geniuses and compassionate leaders, no matter where you look (except, perhaps, in politics, where it seems to be almost entirely idiots…). It just seems that conventional medicine has more than its fair share of short-sighted individuals (which I am equating with the term “idiots”). It’s not just the doctors, of course, but the doctors have played a significant role in promoting the dogmatic beliefs that have helped deliver this disastrous failure of a health care system that we all suffer under in America today. Cuba actually has better health care results than America, and that country has virtually none of the technology, pharmaceuticals and insurance programs that we have.

That says a lot right there. To some, it’s downright hilarious. Personally, I can’t help but laugh at the whole system of western medicine. And I plan to keep making fun of it for as long as it continues to produce more health care follies.

by Mike Adams..News Target

http://www.newstarget.com/022389.html

 

on-the-take.jpg

December 15, 2007 Posted by | Government, Health | , , , , , , , , , , , , , , , , , , | 1 Comment

Flame Retardant Chemical Now In Breast Milk and Detoxification Methods

Flame Retardants: Dangerous chemical now in breast milk

Flame retardant chemicals, which are in household furniture, textiles and electronic equipment, have found their way into human breast milk. Scientists aren’t sure how this may affect the developing child, but it’s feared it may cause neurological problems and disrupt thyroid function.

One study has found that the level of the retardant PBDE (polybrominated diphenyl ethers) has increased 200 times in breast milk in women in North America, while another study in Sweden has discovered the level has increased 60 times in a span of 25 years.

PBDEs have regularly been included in a range of household and office items since the 1970s, but scientists have only recently discovered just how dangerous the chemical can be. Regulators across Europe and the US have banned some elements of the chemical, and the brominated mix will be removed under new legislation that comes into force in 2008.

But items of furniture and furnishings that contain the original compound are still in millions of homes. Unlike other pollutants such as PCBs and DDT, the PBDEs particularly affect infants. Scientists have found a direct link between breast milk and household dust, and they estimate that toddlers’ exposure to PBDEs from household dust is 100 times greater than that for adults because of breast milk and more hand-to-mouth contact.

(Source: The Lancet, 2007; 370: 1813-4)

FAIR USE NOTICE: This blog/bulletin may contain copyrighted material. Such material is made available for educational purposes, to advance understanding of human rights, democracy, scientific, moral, ethical, and social justice issues, etc. This constitutes a ‘fair use’ of any such copyrighted material as provided for in Title 17 U.S.C. section 107 of the US Copyright Law. This material is distributed without profit.

For educational purposes only This information has not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease

Detoxification – for Your Health

Stimulating your detoxification systems can be done through a number of nutrients.

phase 1 Stimulation

· Thngeretin (from tangerines)

· Riboflavin and carotenoids (such as beta-carotene, alpha-carotene, lycopene, lutein, and astaxanthin)

Phase 1 stimulation can render some chemicals toxic – the following nutrients protect against this toxicity.

phase 1 Inhibition

· Hesperidin (oranges)

· Naringenin (grapefruit)

· Resveratrol (grape skins)

· Quercetin (onions, teas, apples, and most vegetables)

· Apigenin (celery, parsley, and ginkgo biloba)

· Ferulic acid (fruits)

· Chlorogenic acid (Mackintosh apples, blueberries, eggplant)

phase 2 Stimulation

· Indole-3-carbinol (broccoli, Brussels sprouts and other cruciferous vegetables)

· Isothiocyanates and sulforaphane (broccoli and Brussels sprouts)

· Thurine (an amino acid – available as a supplement)

· Glutathione (supplied by N-acetyl L-cysteine, ellagic acid and alpha-lipoic acid – all

available as supplements)

· Glycine (an amino acid supplement – high intakes can cause excitotoxicity)

· MSM (methylsulfonylmethane – a supplement)

· Quercetin (teas, onions, cranberries, and most vegetables)

Stinlulation for Both Phase 1 and phase 2

· Curcumin (from the spice turmeric, also a supplement)

· Astaxanthin and canthaxanthin (from all vegetables and fruits and also available as a supplement called mixed carotenoids

Six Additional Supplements That Improve Liver Health

Your liver plays a crucial role in your overall health. Here are nutrients that focus on protecting the liver.

· Lecithin (phosphatidylcholine)

· Curcumin also protects the liver from free radical damage and improves bile flow

· Alpha-lipoic acid has been shown to protect the liver from some extremely powerful toxins and from hepatitis C and A damage.

· Silymarin (extracted from the milk thistle plant) protects the liver and brain and stimulates liver regeneration.

· Vitamin C (as magnesium ascorbate) protects the liver from free radical damage

· Magnesium protects the liver from free radicals and inflammation and increases glutathione levels

 

THE LIVER AND DETOXIFICATION

The liver keeps us clean on the inside and prevents dangerous chemicals from penetrating their way deeper into our bodies. The liver is the gateway to the body and in this day and age has an enormous workload that frequently overloads its detoxification systems. The liver must cope with every toxic chemical in our food chain as well as excessive amounts of unhealthy fats and animal protein that are ubiquitous in fast foods. Let us examine in more detail the mechanisms by which the liver keeps our internal body clean.

THE LIVER FILTER

If we examine the liver under a microscope we see rows of liver cells separated by spaces called sinusoids. Sinusoids are structured like a filter or sieve through which the blood stream is filtered. During this process the filter removes unwanted particulate matter, microorganisms and metabolic waste products. These noxious thing are ingested by specialized cells in the sinusoids called “Kupffer cells” which break down and destroy these things, rendering them harmless. The sinusoids and Kuffer cells are like a “garbage disposal unit” inside the liver. Thus you can see that the liver is the filter and cleanses the blood stream which is of vital importance.

DETOXIFICATION PATHWAYS

Inside the liver cells (hepatocytes) we find sophisticated enzyme pathways or chemical pathways that have evolved over millions of years, to breakdown toxic substances. Every drug, artificial chemical, pesticide and hormone is broken down or metabolized by these pathways inside the liver cells. Basically there are two major detoxification pathways inside the liver cells which are called the Phase One and Phase Two pathways.

PHASE ONE

This is called the cytochrome P450 enzyme system where a liver cell takes a toxic chemical and through a process of oxidation, reduction, hydrolysis or hydroxylation turns it into a less harmful substance. During this process oxygen free radicals are generated, so there is a need for antioxidants, especially Vitamin C, to prevent cellular damage. For efficient phase one detoxification to occur the liver requires adequate amounts of the nutrients selenium, folic acid, vitamins B2, B3, B6, phophatidyl choline and bioflavonoids. If these nutrients are lacking, toxic chemicals will become far more dangerous. Fast foods and processed foods are deficient in these vital liver nutrients. Thus although many people are over-eating they are still suffering with malnutrition which exacerbates toxic overload. Dr. Sandra Cabot’s Liver Cleansing Diet reduces the toxic load on the liver and also provides the vital nutrients required by the liver for detoxification.

PHASE TWO

This is called the conjugation pathway whereby the liver cells add either a glycine or sulphate molecule to a chemical to make it water soluble. It can then be excreted from the body via fluids such as urine or bile. Through conjugation the liver is able to turn drugs (xenobiotics and hormones), neurotransmitters and phenolic compounds into excretable substances. For efficient phase two detoxification the liver requires Vitamin E, carotene, sulphur containing amino acids (taurine, methionine, cysteine), glycine, glutamine, choline and inositol. Cruciferous vegetables (cabbage, cauliflower, broccoli, brussel sprouts) are a good source of natural sulphur compounds for the liver. These things can spike up and support the phase two detoxification system. The liver cleansing diet has been designed to support and enhance the phase one and two liver detoxification systems. If the phase one and two detoxification pathways become overloaded, there will be a build up of toxins in the body. Many of these toxins are fat soluble and incorporate their way into the fatty cell membranes where they may stay for years, if not a lifetime. Some of these toxins, such as pesticides, petrochemicals and aspartame are highly toxic to the nervous system and endocrine glands producing chronic neurological and hormonal dysfunction. They are also carcinogenic and have been implicated in the rising incidence of breast, prostrate and brain cancer. If the filtering and/or detoxification system in the liver are inefficient this will cause harmful substances and micro-organisms to build up in the blood stream. This will increase the workload of the immune system, which may then become overloaded and hyperstimulated. This often is so in symptoms of immune dysfunction such as allergies, inflammatory states, recurrent infections, swollen glands, chronic fatigue or auto-immune disease. These disorders are very common today and usually get treated on a symptomatic basis with drugs. Unfortunately thousands of people visit doctors everyday complaining of these symptoms and rarely does anyone think of the liver. The simplest and most effective way to take the load off the immune system, is to improve liver function. Dr. Sandra Cabot has been able to help many people with chronic immune and liver dysfunction through her LIVER CLEANSING DIET BOOK. In this book she fully explains that you cannot have a healthy immune system if your liver is dysfunctional. This is a revelation for millions of people struggling with poor health. Should the reader be interested, Dr. Cabots book may be ordered by calling 1-888-782-7014.

The Liver Doctor

Calcium-D-glucarate

Introduction

Calcium-D-glucarate is the calcium salt of D-glucaric acid, a substance produced naturally in small amounts by mammals, including humans. Glucaric acid is also found in many fruits and vegetables with the highest concentrations to be found in oranges, apples, grapefruit, and cruciferous vegetables. (1) Oral supplementation of calcium-D-glucarate has been shown to inhibit beta-glucuronidase, an enzyme produced by colonic microflora and involved in Phase II liver detoxification. Elevated beta-glucuronidase activity is associated wire an increased risk for various cancers, particularly hormone-dependent cancers such as breast, prostate, and colon cancers. (2) Other potential clinical applications of oral calcium-D-glucarate include regulation of estrogen metabolism and as a lipid-lowering agent.

Pharmacokinetics

Upon ingestion and exposure to the acidic environment of the stomach, calcium-D-glucarate is metabolized to form D-glucaric acid. D-glucaric acid is further metabolized in the gastrointestinal tract into three compounds existing in equilibrium and comprised of approximately 40-percent D-glucaric acid, 30-percent D-glucaro-1,4-lactone, and 30-percent D-glucaro-6,3-lactone. These compounds are then transported to the blood and various internal organs, and are subsequently excreted in the urine and bile. Although D-glucaro-1,4-lactone seems to be the most pharmacologically active of the three, it is not commercially available. Also, calcium-D-glucarate administration results in longer inhibition of beta-glucuronidase (five hours versus one hour) than does D-glucaro-1,4-lactone, so it is the compound used. (3)

Mechanism of Action

Calcium-D-glucarate’s detoxifying and anticarcinogenic properties are attributed to its ability to increase glucuronidation and excretion of potentially toxic compounds. During Phase II detoxification, chemical carcinogens, steroid hormones, and other lipid-soluble toxins are conjugated with glucuronic acid in the liver (glucuronidation), and excreted through the biliary tract. Beta-glucuronidase is capable of deconjugating these potential toxins, making it possible for them to be reabsorbed rather than excreted. D-glucaro-1,4-lactone is the metabolite that has been shown to inhibit beta-glucuronidase activity, increasing excretion of conjugated xenobiotic compounds and decreasing activity of harmful substances that are most active in their deconjugated state. (4,5) Inhibition of beta-glucuronidase ultimately results in potentially decreasing the risk of carcinogenesis. (6) In addition, by reducing the beta-glucuronidase viability and activity of intestinal bacteria, salts of D-glucaric acid have been shown to enhance enterohepatic circulation and reduce steady state levels of cholesterol synthesis, resulting in decreased serum lipid levels. (7)

Deficiency States

Calcium-D-glucarate is not an essential nutrient so, technically, no deficiency state exists. However, since it is only produced in small amounts by humans, it is important that dietary intake be adequate. Diets low in fruits (particularly oranges, apples, and grapefruit) and cruciferous vegetables (broccoli, cabbage, and brussel sprouts) may result in a relative deficiency of calcium-D-glucarate and its metabolites. Research has shown a low level of D-glucaric acid correlates with a higher level of beta-glucuronidase, which in turn is associated with an increased risk for various cancers. (2)

Clinical Indications

Cancer

The anticarcinogenic properties of D-glucaric acid and its salts have been studied in various animal tumor models, including colon, (8,9) prostate, (2) lung, (10) liver, (11,12) skin, (13) and breast (14-18) cancer, with the mechanism of action for tumor inhibition being very similar in each. These studies demonstrated decreases in beta-glucuronidase activity, carcinogen levels, and tumorigenesis. The preponderance of research, however, has been conducted on mammary tumors in the rat, the animal model most frequently used for breast cancer research.

Breast Cancer

A number of studies have shown calcium-D-glucarate alone, and in combination with retinoids, inhibits mammary carcinogenesis in rats by as much as 70 percent. (3) Natural retinoids have been shown to be effective chemopreventive agents at high doses, but unfortunately the cumulative toxic effects of high doses have restricted their prolonged use. Several studies have demonstrated low-dose retinoids in combination with calcium glucarate interact synergistically to inhibit mammary tumor growth in both animal models and human cell lines. (14-18) The mechanisms responsible for the chemopreventive effects of these two agents may be similar. Both retinoids and calcium-D-glucarate inhibit carcinogenesis during the promotion and initiation phases. Calcium-D-glucarate inhibits protein tyrosine kinase-C activity and induces transformation growth factor beta, possibly resulting in an increase in cellular differentiation and slower progression through the cell cycle. (15) Retinoids induce many of these same biochemical effects. (19) Additionally, calcium-D-glucarate enhances glucuronidation and subsequent excretion of carcinogens and other cancer-promoting agents.

Published human studies on calcium-D-glucarate and breast cancer are few but, due to the encouraging results of the animal studies, the National Cancer Institute has initiated a Phase I trial in patients at high risk for breast cancer at Memorial Sloan Kettering Cancer Center. This trial is examining the use of calcium-D-glucarate as an alternative to tamoxifen’s blocking of estrogen receptors. Preliminary results are quite encouraging and due to calcium-D-glucarate’s excellent safety profile, it may be a more effective option than tamoxifen, which has numerous side effects. (3) Other human trials are being conducted at M.D. Anderson Cancer Center in Houston, Texas and AMC Cancer Research Center in Denver, Colorado.

Colon Cancer

Studies in rats have shown D-glucarate salts to inhibit colon carcinogenesis alone and in combination with 5-fluorouracil (5-FU). In one study, D-glucarate markedly inhibited azoxymethane-induced colon carcinogenesis as evidenced by a 60-percent reduction in both tumor incidence and multiplicity. It was hypothesized that malignant cell proliferation was suppressed by inhibition of beta-glucuronidase. Another possible mechanism may involve alterations in cholesterol synthesis or its conversion to bile acids. (8) The second study demonstrated that salts of D-glucarate, in combination with 5-FU in rat colon tumor explants, resulted in a potentiation of 5-FU’s antitumor activity. D-glucarate alone also showed antitumor activity. (9)

Liver Cancer

Hepatocarcinogenesis is thought to be preceded by premalignant hepatic foci that are subsequently transformed to malignant cells. Two separate rat studies by a group of researchers at Ohio State University have demonstrated calcium-D-glucarate delays the appearance of altered hepatic foci and significantly inhibits hepatocarcinogenesis, if given during both the initiation and promotion phases. Maximal inhibition was obtained when calcium-D-glucarate was administered by gavage prior to the carcinogenic agent, diethylnitrosamine. (11,12)

Lung Cancer

A study conducted on mice demonstrated calcium-D-glucarate inhibits benzo[a]pyrene’s ability to bind DNA and induce pulmonary adenomas. (10) Another unpublished phase I clinical trial of 62 patients found D-glucaric acid levels were approximately 29-percent lower in smokers than non-smokers. Regardless of gender, K-ras (an oncogene linked to lung cancer) mutations were found to be present in 38 percent of subjects who smoked, while no K-ras mutations were found in the non-smoking control subjects. It was hypothesized that D-glucaric acid deficiency correlates with K-ras mutations and might be indicative of a higher risk for developing lung cancer. (20)

Skin Cancer

The efficacy of dietary calcium-D-glucarate as a chemopreventative agent has also been studied in the mouse skin tumorigenesis system. Mice were given 7,12-dimethylbenz[a]anthracene (DMBA) to induce skin tumorigenesis and were fed either a regular chow diet or a chow diet fortified with calcium-D-glucarate. When fed the calcium-D-glucarate chow through both the initiation and promotion phases, papilloma formation was inhibited by over 30 percent. The data indicate that supplementation of calcium-D-glucarate results in a marked alteration in the retention, activity, and metabolism of carcinogenic substances. (13)

Estrogen Metabolism

Calcium-D-glucarate’s inhibition of beta-glucuronidase activity allows the body to excrete hormones such as estrogen before they can become reabsorbed. Oral administration of large doses of calcium-D-glucarate have been shown to lower serum estrogen levels in rats by 23 percent. (21) Because many breast cancers are estrogen-dependent, calcium-D-glucarate’s ability to affect estrogen and other hormone levels has led to Phase I clinical trials at several major cancer centers in the United States. Results of these studies are pending.

Lipid Lowering

Side effects of currently available hypolipidemic agents present a need for safe and effective lipid-lowering agents. D-glucarates have been shown to significantly reduce total serum cholesterol in rats by as much as 12-15 percent and LDL-cholesterol by 30-35 percent. Preliminary results in humans show D-glucarate reduced total serum cholesterol up to 12 percent, LDL-cholesterol up to 28 percent, and triglycerides up to 43 percent. The lipid-lowering effect of calcium-D-glucarate may be attributed to improved enterohepatic circulation, resulting in increased excretion of bile acids and a reduction in steady state levels of cholesterol biosynthesis. (7)

Drug/Nutrient Interactions

There are no known drug interactions with calcium-D-glucarate, but many drugs and hormones are metabolized in the liver via glucuronidation. Therefore, taking calcium-D-glucarate may increase elimination of these substances, possibly reducing their effectiveness.

Side Effects and Toxicity

No adverse effects have been observed after prolonged feeding to rats or mice at concentrations of 70, 140, or even 350 mmol/kg. (6) Preliminary results of clinical trials in humans have shown calcium-D-glucarate is without adverse effects.

Dosage

The recommended oral dosage of calcium-D-glucarate is generally in the range of 1500-3000 mg daily. Until human trials have been completed the optimal dosage remains elusive.

References

(1.) Dwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on beta-glucuronidase activity and glucarate content of certain vegetables and fruits. Biochem Med Metab Biol 1990;43:83-92.

(2.) Walaszek Z, Szemraj J, Narog M, et al. Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention. Cancer Detect Prev 1997;21:178-190.

(3.) Heerdt, AS, Young CW, Borgen PI. Calcium glucarate as a chemopreventive agent in breast cancer, Isr J Med Sci 1995;31:101-105.

(4.) Horton D, Walaszek Z. Conformations of the D-glucarolactones and D-glucaric acid in solution. Carbohydr Res 1982;105:95-109.

(5.) Walaszek Z, Hanausek-Walaszek M. D-glucaro-1,4-lactone: its excretion in the bile and urine and effect on biliary excretion of beta-glucuronidase after oral administration in rats. Hepatology 1988;9:552-556.

(6.) Selkirk JK, Cohen GM, MacLeod MC. Glucuronic acid conjugation in the metabolism of chemical carcinogens by rodent cells. Arch Toxicol 1980;139:S171-S178.

(7.) Walaszek Z, Hanausek-Walaszek M, Adams AK, Sherman U. Cholesterol lowering effects of dietary D-glucarate. FASEB 1991;5:A930.

(8.) Yoshimi N, Walaszek Z, Moil H, et al. Inhibition of azoxymethane-induced rat colon carcinogenesis by potassium hydrogen D-glucarate. Int J Oncol 2000;16:43-48.

(9.) Schmittgen TD, Koolemans-Beynen A, Webb TE, et al. Effects of 5-fluorouracil, leucovorin, and glucarate in rat colon-tumor explants. Cancer Chemother Pharmacol 1992;30:25-30.

(10.) Walaszek Z, Hanausek-Walaszek M, Webb TE. Dietary glucarate-mediated reduction of sensitivity of murine strains to chemical carcinogenesis. Cancer Lett 1986;33:25-32.

(11.) Oredipe OA, Barth RF, Hanausek-Walaszek M, et al. Effects of an inhibitor of beta-glucuronidase on hepatocarcinogenesis. Proc Am Assoc Cancer Res 1987;28:156.

(12.) Oredipe OA, Barth RF, Hanausek-Walaszek M, et al Effects of calcium glucarate on the promotion of diethylnitrosamine-initiated altered hepatic loci in rats. Cancer Lett 1987;38:95-99.

(13.) Dwivedi C, Downie AA, Webb TE. Modulation of chemically initiated and promoted skin tumorigenesis in CD-1 mice by dietary glucarate. J Environ Path Toxicol Oncol 1989;9:253-259.

(14.) Abou-Issa H, Koolemans-Beynen A, Meredith TA, Webb TE. Antitumour synergism between non-toxic dietary combinations of isotretinoin and glucarate. Eur J Cancer 1992;28:784-788.

(15.) Webb TE, Abou-Issa H, Stromberg PC, et al. Mechanism of growth inhibition of mammary carcinomas by glucarate and the glucarate:retinoid combination. Anticancer Res 1993; 13:2095-2100.

(16.) Bhatnagar R, Abou-Issa H, Curley RW, et al. Growth suppression of human breast carcinoma cells in culture by N-(4-hydroxyphenyl) retinamide and its glucuronide and through synergism with glucarate. Biochem Pharmacol 1991 ;41:1471-1477.

(17.) Curley RW, Humpries KA, Koolemans -Beynan A, et al. Activity of d-glucarate analogues: synergistic antiproliferative effect in cultured human mammary tumor cells appear to specifically require the d-glucarate structure. Life Sci 1994;54:1299-1303.

(18.) Abou-Issa H, Moeschberger M, Masry EI, et al. Relative efficacy of glucarate on the initiation and promotion phases of rat mammary carcinogenesis. Cancer Res 1995;15:805-810.

(19.) DeLuca LM. Retinoids and their receptors in differentiation, embryogenesis and neoplasia. FASEB J 1991;5:2924-2933.

(20.) Walaszek Z, Raich PC, Hanausek M, et al. Role of D-glucaric acid in lung cancer prevention. Unpublished research. AMC Cancer Research Center, Denver, CO.

(21.) Walaszek Z, Hanausek-Walaszek M, Minto JP, Webb TE. Dietary glucarate as anti-promoter of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis. Carcinogenesis 1986;7:1463-1466.

COPYRIGHT 2002 Thorne Research Inc.
COPYRIGHT 2002 Gale Group

Activated Charcoal

Universal Antidote and Detoxifier

By Richard C. Kaufman, Ph.D.

Activated charcoal is a highly absorbent gritty black material commonly found in air and water filters. Activated charcoal is created by carbonizing organic matter in a kiln under anaerobic conditions and activating the material with oxidizing gases like steam or air at high temperatures. This oxidative process erodes the charcoals internal surfaces and increases its adsorption capacity by creating an internal network of very fine pores. Usually bone char, coconut shells, peat, coal, petroleum coke, and sawdust are the starting materials for making activated charcoal.Early Uses Of Charcoal
The medical uses for charcoal date back to the Egyptian Papyrus of 1550 B.C. During the time of Hippocrates (400 B.C.) physicians treated epilepsy and anthrax with charcoal. In the 1700s charcoal was often prescribed for bilious problems (excessive bile excretion). After the development of the charcoal activation process (1870 to 1920), many reports appeared in medical journals about activated charcoal as an antidote for poisons and a cure for intestinal disorders.Contemporary Charcoal Use
Modern research has validated most of the early uses for charcoal and discovered exciting new applications. This article will discuss the many important therapeutic uses for activated charcoal;(1,6)

  1. Universal antidote for drugs, chemicals and poisons.

  2. Systemic clearance of drugs and intoxicants.

  3. General detoxification.

  4. Anti-aging and life extension.

  5. Reducing cholesterol, coronary disease and arteriosclerosis.

  6. Counteracting pathogens.

  7. Intestinal complaints.


Antidote For Drugs, Chemicals and Poisons
Activated charcoal has the well-earned reputation of being a universal antidote. It can adsorb most organic chemicals, many inorganic chemicals and countless poisonous substances before they can cause harm. How well activated charcoal really works in practical situations depends on several different factors:(8)

  1. The type of toxicant (its chemical structure and physical properties)

  2. The amount and type of charcoal ingested.

  3. The length of time from toxin ingestion to activated charcoal ingestion.

  4. The contents of your intestinal fluids and intestinal transport efficiency.


As a general rule, a single large dose of activated charcoal should be taken as soon as possible after ingesting a poison. The amount of activated charcoal should exceed the toxic substance by a factor of eight (a ratio of 8:1). In other words, if youre poisoned with 5 grams of a chemical, you need to take at least 40 grams of activated charcoal. Other researchers recommend different dosages. Some experts believe a 10 to 1 ratio is correct. Still other experts recommend a fixed amount of 50 to 100 grams. I recommend ingesting a minimum of 50 grams of activated charcoal as a counterpoison, because ingesting large amounts of activated charcoal is harmless, and taking too little is ineffective. Besides, how often in the case of an emergency can you precisely determine the amount of the poison?The actual effectiveness of the activated charcoal will vary, so take more than you think you require. Activated charcoal should be taken within 30 minutes of ingesting the poison. The longer the delay, the less effective activated charcoal will be. On some poisons delaying more than 30 minutes decreases the effectiveness of the activated charcoal as an antidote by up to 60%. The bottom line is plain and simple. Keeping activated charcoal in your medicine cabinet and taking it if you are poisoned could save your life and your money too. It has been estimated that use of activated charcoal for treating poisonings could reduce the stay in intensive care from 3 or 4 days to one, saving over $100,000,000 in health care costs and preventing unnecessary disability and death.(11)Systemic Clearance of Drugs and Intoxicants
Nowadays, activated charcoal is often used to clear drugs and intoxicants that can enter the body through the intestinal tract, and even by injection and other routes. The systemic clearance of toxic substances or detoxification by activated charcoal is accomplished by taking multiple daily doses. Activated charcoal detoxifies the body in several manners:(4)

  1. Purifies the 6-8 liters of digestive fluids that are secreted daily which in turn helps remove foreign substances from the blood.

  2. Absorbs the intoxicant substance and its metabolites that are excreted into the small intestine from the biliary (bile) tract, preventing their reabsorption.

  3. Absorbs drugs that diffuse back into the stomach and intestines.

  4. Decreases the detoxification work load of the liver.


Activated charcoal shortens the time it takes an intoxicant to leave the system and decreases the duration and intensity of symptoms.(15) People who take activated charcoal after drinking alcohol or taking recreational drugs such as cocaine or amphetamines recover quicker. I recommend activated charcoal as part of a drug recovery program to ease withdrawal symptoms and reduce drug craving. Other nutrients that help are the neurotransmitter precursors L-Tyrosine, L-Tryptophan, L-Phenylalanine, Choline and DMAE (Dimethylaminoethanol).Even experts disagree on the best way of using multiple doses of activated charcoal to remove intoxicants. Most protocols are based on experience with drug overdosages. In actual clinical situations, the activated charcoal regimen is optimized to the patient. The doctor considers the type of toxic substance, severity of intoxification, digestive functions and electrolyte balance. For mild overdoses and intoxification, I suggest up to 80-100 grams divided into 4-6 daily doses of powdered activated charcoal until the symptoms are eliminated. Consult an expert who can optimize your regimen. For a dangerous overdosage call your physician or hospital imwww.ely.General Detoxification
Very few health practitioners realize that activated charcoal is the best single supplement for enhancing detoxification. Detoxification is an on-going biological process that prevents toxins (from infectious agents, food, air, water, and substances that contact the skin) from destroying health. Chronic exposure to toxins produces cellular damage, diverse diseases, allergic like reactions, compromised immunity and premature aging.(14)To use activated charcoal in a detoxification plan, I recommend about 20 grams a day of powdered activated charcoal be taken in divided daily doses for several months or the duration of the detoxification program.

In addition to activated charcoal, the ideal detoxification prescription includes sauna baths, exercise, a special diet, and supplements (unsaturated fatty acids, vitamin C, niacin, proteolytic (protein digesting) enzymes, liver support phytonutrients and a comprehensive multiple nutrient formula.(9)

Anti-Aging and Life Extension
Dr. V. V. Frolkis, a famous Russian Gerontologist, and his colleagues have discovered that activated charcoal is a potent life-extending agent. Activated charcoal has been found to increase the mean lifespan of older test animals by approximately 40% and their maximum lifespan by approximately 34%.(2)

  1. Activated charcoal decreases the age-related increase in the brains sensitivity to drugs and toxins.

  2. Activated charcoal normalizes cholesterol and lipid metabolism.

  3. The regular use of activated charcoal improves the adaptive functioning of essential organs (the liver, kidneys, and adrenals). That translates into better defense mechanisms.


Microscopic tissue analysis shows that activated charcoal prevents many cellular changes associated with aging-decreased protein synthesis, lower RNA activity, arteriosclerosis, and organ fibrosis. So the cumulative effects from activated charcoal are longer life and improved overall health.(19)A recommended protocol for anti-aging and life extension benefits is as follows: On two consecutive days each week, take about 30 grams each day of powdered activated charcoal in divided daily doses. Take charcoal in the morning, at midday and before bed on an empty stomach. Avoid excessive calories or unhealthy foods on those days.Reducing Cholesterol and Coronary Artery Disease
You can help your heart and circulatory system by taking activated charcoal. Activated charcoal lowers the concentration of total lipids, cholesterol, and triglycerides in the blood serum, liver, heart and brain. In one study that was reported in the British journal, Lancet, on patients with high cholesterol, 8 gm of activated charcoal taken three times a day lowered total cholesterol 25%, lowered LDL cholesterol 41% and doubled their HDL/LDL (high-density lipoprotein/low-density lipoprotein) cholesterol ratio. Microscopic tissue examination studies have shown that a daily dose of activated charcoal may prevent sclerotic changes in the heart and coronary blood vessels. To help your heart and blood vessels, I suggest the following: 12-17 grams of activated charcoal twice a day for one month under the guidance of a physician who can measure cardiovascular improvements and cholesterol levels.(5,15)Counteracting Pathogens
Activated charcoal reduces the activity of some viruses. So if you catch a cold or the flu, try activated charcoal. You may suffer less and heal faster. Activated charcoal also prevents the poisonous activity of many harmful bacteria in the human body by adsorbing the toxins and enzymes that they generate. Studies have shown that activated charcoal is an effective treatment for dysentery, cholera, and many infectious conditions of the digestive tract.(16,17)

Systemic Candidiasis
Activated charcoal can be an effective adjunct to any regimen for the treatment of systemic Candida albicans infections. Activated charcoal adsorbs much of the toxins that Candida produces that otherwise would be absorbed by the blood and carried throughout the body. These toxins produce pathological changes in tissues and organs and interfere with proper immune function. Candida toxins cause allergic reactions and are responsible for the debilitating symptoms of Candidiasis.

Activated charcoal also suppresses the growth of intestinal-based yeasts.(3) Activated charcoal counteracts the Herxheimer reaction–a severe, short-term exacerbation of Candida symptoms caused by the copious amount of toxins produced by dying yeast cells. The Herxheimer reaction is often so unpleasant that patients abandon treatment before completion. Activated charcoal is one method for alleviating the symptoms of yeast die-off so people can continue their treatment and not suffer.

I suggest 20-30 grams of powdered activated charcoal a day in divided dosages on an empty stomach until the problem is eliminated. The larger amount is taken for more severe situations. Again, a reminder: do not take required medications within 2 hours of taking activated charcoal.

Intestinal Complaints
Activated charcoal has been used by physicians since the last century to treat various intestinal complaints. Abdominal distension (bloating) and flatulence respond favorably to treatment with activated charcoal. Diarrhea caused by food poisoning, bacteria, nervousness and other factors is usually alleviated by taking activated charcoal.(10) Some physicians have used activated charcoal to stop bleeding from ulcerative colitis and calm spastic colons.(12) Activated charcoal is the best intestinal deodorant available. Taking activated charcoal counteracts decomposition products from food (such as beans) that cause flatulence and diarrhea. Individuals with malodorous stools should reach for activated charcoal. Travelers to foreign countries would be wise to pack activated charcoal. In my opinion, activated charcoal is the most practical way to effectively counteract food poisoning. To alleviate intestinal disorders with activated charcoal, I recommend the following. As an antidote for food poisoning, take 20 grams of activated charcoal two to three times daily. For other intestinal complaints, 5 to 10 grams of powdered activated charcoal twice daily.

Charcoal Is Safe
Toxicology studies have proven that activated charcoal is basically harmless. Ingesting high dosages does not interfere with sleep, appetite or well being–or cause major problems. There are several undesirable effects of using activated charcoal that can be avoided by complying with the following directions. Activated charcoal is highly adsorbent; when it is ingested at the same time as medication, supplements and foods it may decrease their absorption and utilization. Therefore, always allow 2 hours before and wait 2 hours after using activated charcoal to eat, take supplements or swallow medication. Activated charcoal has a natural tendency to cause constipation. That can be counteracted by taking a mild herbal laxative with the activated charcoal. Finally activated charcoal harmlessly blackens your stools. Although black-gray stools look strange, they can be used to calculate your bowel transit time. Just measure the length of time from taking activated charcoal to the appearance of darkened stools.

Not All Charcoal is Alike
Numerous companies manufacture activated charcoals, each of which can have different adsorptive capacities. Different source materials and manufacturing procedures give each brand of activated charcoal its own pore diameters and internal volume that determine its adsorption capacity. The U.S.P. (United States Pharmacopoeia) standard for activated charcoal specifies an internal surface area of 1000 m2/g (square meters per gram). Recently, several companies have begun manufacturing Super activated charcoals, with up to 3 times the internal surface area per gram and far greater adsorption power than standard activated charcoal.(3)

Powders, Capsules, or Tablets?
Because of the large volume of charcoal that is needed, it is easiest to take liquid preparation of charcoal powder. For example, to take 30 grams of charcoal a day in capsules would require that you swallow about 60 capsules. Furthermore, activated charcoal tablets are not effective. They take too long to disintegrate and release the activated charcoal.

Ideal Charcoal Preparation
Unfortunately, a simple water and charcoal mixture is unpalatable and messy. It tastes like a charcoal briquette, and blackens your teeth, gums and tongue. These problems can be avoided by ingesting a powdered activated charcoal complex that contains a thickening agent like bentonite, with added flavors and mild sweeteners.

Research studies showed that that the addition of bentonite significantly improved the palatability of an activated charcoal and water slurry. Bentonite acts as thickening agent that reduces powdery mouth-feel and improves the taste without reducing the efficacy of activated charcoal. In fact, bentonite is an enterosorption agent and a poison antidote in its own right. For example, bentonite has been shown to bind and reduce the poison paraquat. The addition of chocolate further enhances the palatability of activated charcoal in research studies and practical experience.(12,13)

Reprinted with permission of Journal Of The Megahealth Society, Vol. 5, No. 3, Issue #23 ISSN 0891-5334. Copyright 1989 by MegaHealth Society, now Cognitive Enhancement Research Institute (CERI), publishers of Smart Life News. CERI explores the latest research and treatment for Alzheimerss, Parkinsons, Downs syndrome and age-associated mental impairment in normal, healthy adults.

References
D.O. Cooney, Activated Charcoal Antidotal and other Medical Uses. Marcel Dekker, New York and Basel, 1983.

V. Frolkis, et al., Enterosorption in prolonging old animal life. Exp. Gerontol. 19; 217-25, 1984.

E.P. Krenzelok and M. B. Heller, In vivo comparative effectiveness of five commercial activated charcoal products. Vet. Hum. Toxicol, 28; 498, 1986.

K. Kulig, et al., Management of acutely poisoned patients without gastric emptying. Ann. Emerg. Med. 114:562-67, 1985.

P. Kuusisto, et al., Effect of activated charcoal on hypercholesterolemia. Lancet 16: 366-67, August 1986.

J. Mattson and H. J. Mark, Activated Carbon. Marcel Dekker, New York and Basel, 1971.

G. Park, et al., Expanded role of charcoal in the poisoned and overdosed patient. Arch. Int. Med. 146: 969-73, 1986.

Reduction of Human Organchalide Burdens, Foundation for Advancements in Science and Education, Los Angeles, California, 1983.

J. A. Riese and F. Damrac, Use of activated charcoal in gastroenterology: value for flatulence and nervous diarrhea. J. Am. Ger. Soc. 12: 500, 1964.

W. Watson, Factors influencing the clinical efficacy of activated charcoal. Drug Intelligence and Clinical Pharmacy 21: 160-66, 1987.

Navarro RP; Navarro KR; Krenzelok EP Relative efficacy and palatability of three activated charcoal mixtures. Vet Hum Toxicol, 19(8):6-9 1980 Feb.

Gwilt PR; Perrier D Influence of thickening agents on the antidotal efficacy of activated charcoal. Clin Toxicol, 19(8):89-92 1976.

Topuzov EG; Beliakov NA; Malachev MM; Umerov AK; Solomennikov AV; Gritsenko IV; Kokaia AA Use of enterosorption in biliary tract cancers complicated with mechanical jaundice. Vopr Onkol, 42(2):100-3 1996.

Beloshitski(r)i VV A clinico-biochemical basis for the use of enterosorption in severe craniocerebral trauma Lik Sprava, 42(5):145-8 1997 Sep-Oct.

Krylov AA; Beliakov NA; Sapego AV; Stolov SV Enterosorption in ulcerative lesions of the gastrointestinal tract with concomitant intestinal dysbacteriosis Ter Arkh, 68(2):24-7 1996.

Riechkina OO A clinical assessment of the detoxifying effect of enterosorption in treating tuberculosis of the respiratory organs in children Lik Sprava, 5(5):62-4 1998 Aug.

Andreichyn MA; Lutsuk OS; Andreichyn SM; Kopcha VS [The enterosorption treatment of patients with acute intestinal infections and chronic colitis with diarrhea Lik Sprava, EA-(7-9):147-51 1996 Jul-Sep.

Andreichyn MA; Lutsuk OS; Andreichyn SM; Kopcha VS Enterosorption as a method for prolonging life. Fiziol Cheloveka, 22(7-9):131-5 1996 May-Jun.

Check out these sites for more Information about detoxification. In addition search the internet for Pectin,chlorela,cilantro,DMSA,EDTA,Humic Acid and Calcium bentonite clay, these are also very good detoxifying agents along with sodium Alginate which binds with radioactive substances. Soon I hope to do a more indepth post about detoxification

http://healingtools.tripod.com/char3.html

http://www.iherb.com/ProductDetails.aspx?c=1&pid=1089&at=0

http://home.earthlink.net/~moriam/

http://www.nydetox.org/elements.htm

http://www.liverdoctor.com/

December 10, 2007 Posted by | Detoxification, Health | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , | 1 Comment

Fighting Free Radicals: The Role of Bark Extractives

 

Fighting Free Radicals: The Role of Bark Extractives

by Kelvin Duncan, Ph.D. (more info)
listed in antioxidants, originally published in issue 44 – September 1999

A stand of young Pinus radiata

The rapidly growing volume of evidence in the scientific literature about the nature and role of free radicals has lead to an increasing awareness of their importance in health and disease. Free radicals have been implicated in a great number of human conditions and the literature on the subject is vast (Ames et al., 1993, Bland, 1995, Diplock, 1994, Halliwell, 1996 and the references in Table 1).

Table 1. Recent references to health conditions in which flavonoids are thought to be beneficial.

Disease/Benefit
Degenerative disease/ helps prevent or slow down
General diseases/ prevents or ameliorates
Cancer and cardiovascular/ protects
Inflammatory bowel disease/ helps
Heart attacks/ reduced risk
Strokes/ reduced risk
Clots/ prevent abnormal clots
Endothelial cells/ protect and strengthens
Plaque/ reduced rate of formation
Hair/ increases hair growth and follicle cell density
Anti-inflammatory, esp. arthritis/ reduces

Oedema/ reduces
Tumours/ inhibits early tumours
Tumours/ reduces incidence of spontaneous tumours in elderly mice
Allergies/ anti-allergenic
Carcinogens and mutagens/ chemoprotective
Skin cancer/ reduces or prevents skin cancers induced by UV
Prostate cancer/ anticarcinogenic against prostate cancer
Insulitis/ protect pancreas and help lower or prevent insulitis
.

HIV, may help HIV

Reference
Ames et al., 1993

.
Cross et al., 1987
Gey, 1993
Grishanan, 1994
Hertog et al., 1993
Keli et al., 1996
Rice-Evans, 1996
Kaneko et al., 1999
Xu et al., 1998
Takashashi et al., 1999
You et al., 1999
Pelzer et al., 1998,
Lairir-Chatterjee et al., 1999
Duncan, 1998
Cheong et al., 1998
Sohn et al., 1998

.
Ahmad et al., 1998
.

Zi et al., 1998
Soto, et al., 1998
Scrhramm & German, 1998
Kitamura, et al., 1998

However, not all free radical reactions in the body are harmful; some are entirely natural and are necessary for the correct functioning of many metabolic processes. (Cheesman and Slatter, 1993). These benign, natural free radicals do not concern us here since they are well controlled by the body’s metabolism. Rather it is the damaging free radicals, which are largely caused by non-natural events, that are the focus of this article.

How do free radicals form?

Free radicals can form naturally since some of the body’s molecules have weak bonds that spontaneously break and cause the molecule to become a free radical. Also, for unknown reasons a small proportion of normal oxidative reactions result in the formation of free radicals. Other causes of damaging free radicals are ionising radiation, such as light, or ultra violet, or other forms of radiation. Mariner’s skin, that scourge of skin which makes people look far older than they really are, is a result of excessive exposure to light and to UV radiation: the skin changes in thickness, it becomes dehydrated, its collagen becomes thickened and hardened, and wrinkles and dryness result. Radioactivity, whether from natural or man made sources, also causes free radicals to form. Finally, a great number of chemicals, especially human-
produced synthetic compounds can cause free radical formation.

Antioxidants

The damaging effects of free radicals can be countered by antioxidants. These work by either stopping free radical damage by donating an electron without becoming a damaging free radical themselves, or by preventing oxidation commencing.

There are three main types of antioxidants that are important in human metabolism. These are: antioxidant enzymes produced by the body; essential nutritional dietary compounds such as vitamin C, and small plant-derived substances which intercept free radicals and prevent them from causing damage. The full range of antioxidants found in the body include vitamins C and E, carotenes, glutathionine, uric acid, taurine, and plant flavonoids and flavonoid derivatives, and some other compounds. This article considers only the flavonoids, which are small compounds synthesised by plants, but not animals, so must be taken in our diet. They are water soluble compounds based on a unit involving carbon ring structures containing phenols (-OH) groups. There are more than four thousand known, not all of which have antioxidant activity, and a great number remain to be discovered (Colgan 1994). They scavenge free radicals without becoming themselves becoming damaging free radicals or causing other chemical species to become free radicals.

In living plants, flavonoids are produced as pigments, defences against fungi and bacteria, anti-parasitics, and as antioxidants protecting against cellular oxidative stress.

Tree bark in history

Tree bark is a particularly rich source of a wide variety of kinds of medicinal compounds, and this has been known to many cultures for many centuries. Two thousand years ago Hippocrates, the Greek physician known as the father of medicine, recommended chewing on white willow bark to relieve pain and fever. In England, this was a common practice in the Renaissance. The active ingredient was isolated in 1828 and was given its current name, salicylic acid in 1938. It was stabilised in 1897 as acetylsalicylic acid. Even though the new product enjoyed great market success, its mode of action was not known until John Vane, a British Pharmacologist, found that they inhibited the body’s production of prostaglandins that promote inflammation and thereby cause pain. Vane received a Nobel Prize for this work. Salicylic acid, a natural product, has been found to have widespread and beneficial effects on many human conditions, including heart attacks and strokes (Graeda and Ferguson 1993).

Decoctions or infusions of barks and leaves were commonly used as poultices and therapies throughout Europe and Asia. The great navigator, Captain James Cook, was well aware of the value of bark and leaves as antiscorbutics (antiscurvy agents). After an enormously long and difficult voyage to New Zealand he would set out to collect materials for “spruce beer”, an optimistic name designed, no doubt, to make the bitter concoction more palatable to his reluctant crew. Spruce, or white, or Norwegian beer was well known then, as it continues to be today, and even if not loved, it was at least accepted for its effects! But Cook’s spruce beer was neither spruce, nor was it beer. What it was is revealed in a letter he wrote to the errant Furneaux, the captain of the accompanying ship on the second of Cook’s voyages. Unlike Cook, Furneaux had a serious scurvy problem amongst his crew because he had not previously followed Cook’s detailed instructions. So, in his letter Cook gave instructions to “brew” beer of the inspissated (thickened) juice of wort, essence of spruce and tea plants. By spruce he meant anything that vaguely resembled spruce, since there was then no spruce in New Zealand, and by tea plants he meant manuka-like plants. Manuka is a ubiquitous and cheerfully scruffy charmer of a scrub or small tree in New Zealand. Like many plants, Manuka contains powerful anti-microbial compounds and other useful biologically active ingredients. Recent work has shown that those evergreen southern equivalents to conifers, the Podocarps, to which Cook’s “spruce” belongs, have an abundance of flavonoids . As much as they hated his brews, Cook’s crews did consume them and their health was remarkably good (Hough 1994). Cook delivered a paper to the Royal Society describing his work in conquering scurvy and other health problems on long sea voyages. He did not claim to have discovered the health benefits of vegetables and plant extracts, as others had experimented with such diets and treatments earlier, but his fame was such that he was greatly instrumental in popularising them to the enormous benefit of seafarers’ health.

Asian cultures used bark extensively to treat and heal. Indian Ayurvedic medicine has a 5000 year history. Punarvasu in about 800 BC, wrote the Susrita Samhita which describes 1500 plants and 300 medicines of therapeutic value. Barks are important components of Ayurvedic practice. The bark of the arjuna tree has been used for at least 3000 years for the treatment of heart failure and for reducing the swelling due to fluid accumulation in ankles and legs when the heart is not pumping properly. This traditional use has been confirmed by western science and it is used by many healers today including Western-trained healers.

The dried bark of the varuna tree has provided relief from kidney and bladder stones. It is now being used in Western medicine to prevent stone formation and related urinary tract infections (Chevellier 1996).

The Chinese, too, have used bark products in their traditional medicine for very many centuries. A herbal and medicinal source book, written over 2500 years ago, the Shen Nung Pen Tsao Ching of China lists over 360 medicinal drugs made from plants. Barks are used extensively. Every Chinese herbalist uses a wide variety of barks, each with its own characteristics and specific uses. Cinnamon, the dried bark of Cinnamomum cassia, is used to control fever and diarrhoea, to aid menstrual problems, and to soothe indigestion. Recently, scientific medicine has confirmed its potency as an antiseptic agent and has shown its potency in reducing the insulin dependency in diabetics. Magnolia barks are prescribed in Chinese herbal medicine as a skeletal muscle relaxant, analgesic and anti-hypertensive. Phelledendron spp., are commonly prescribed to treat diarrhoea and inflammation (Griggs, 1993).

Extensive research in China and Japan is elucidating the active ingredients in these remedies, but only a small fraction of the myriad complex compounds in bark have been identified.

Polynesian and American indigenous people also made use of bark (Whistler, 1991; MacDonald, 1993, Garrett and Garrett, 1996; Wyatt, 1994).

Industrial preparation of flavonoids

Today, various barks are used extensively for health purposes. Following the great success of Taxol, there has been a massive search by ethnobotanists and biochemists for useful bark extractives and a number of useful substances have been discovered. Bark flavonoids are amongst the most useful. They can be extracted industrially using solvent extraction or hot water extraction. This process isolates and concentrates the flavonoids by partitioning them between two different phases of mutually insoluble solvents – like oil and water. More of the desired compounds dissolve in one phase and the unwanted material in the other so it is then easy to separate the two phases mechanically. Further purification can be undertaken by “salting out” – precipitation of the desired material by adding increasing amounts of common salts, such as magnesium sulphate. The salt remains in solution but throws the less soluble flavonoids out of solution as a precipitate so they can be collected. The trouble is that these two processes, solvent partitioning and salting out, do not yield completely pure products. Some of the undesirable compounds get through, necessitating repeated cycles of solvent extraction and salting down in order to obtain yields of sufficient purity. But three main problems still remain with this approach: solvent residues may contaminate the product, undesirable by-products may contaminate the product, and micro-organisms may survive the processing to be present in the product. Furthermore, the process is expensive.

In contrast, the process used to produce a recent new product – enzogenol – is based on water extraction in the absence of oxygen (to prevent the possibility of oxidation of the flavonoids) of clean and selected bark from the Monterey Pine – a coastal species from the Pacific Northwest of North America which is grown extensively in New Zealand. The desired mixture of flavonoids can be selected from the decoction or liquor by a purely physical process. This excludes all the undesirable by- products and micro-organisms to yield a very pure product of controlled composition. The by-products are used as a soil enhancer, so no wastes are produced from the process. Even the water can be recycled (Gilmour in Duncan, 1998).

Bark as a source of antioxidants

Why should bark contain so many antioxidants? The reason is that oxidative stress is a great problem faced by the stem of trees. Stems are intended to last many decades or centuries, so that they have to have powerful and long-lasting protection against attack, decay and disease. Bark is the structure that performs this protection, and since oxygen diffuses from the outside of the stem through the bark, antioxidants are present in the bark and the tissues immediately underneath it so as to provide protection in the event of free radical formation.

Table 2. Kinds of flavonoids and their origin
The six classes of flavonoids:
flavonones, found in citrus
flavones, found in herbs
flavonols, found in all fruits and vegetables
isoflavonoids, found in legumes
anthocyanidins and flavans, found in fruits.None are synthesised by animals, and our sources are entirely from the plants we eat. We should eat a wide variety of types and not rely on only a few.

Human metabolism does produce some antioxidants naturally, but these are not sufficient to combat all the free radicals formed in our bodies. We rely on dietary sources to augment and complete our defences. The trouble is that the rate of formation of free radicals has probably increased over the last few centuries due to increas- ing sources of free radical forming agents as industrial processes extend further and further into our lives. Further- more, our diet has become more and more deficient in free radicals owing to changing dietary habits away from sources rich in antioxidants (raw leafy vegetables, onion, nuts, fruits) toward overly processed foods from which flavonoids, Vitamin E and many other nutrients have been removed. More people are living longer, so these two influences are affecting more and more people. It seems a great pity that modern food processors exploit our two Achilles heels of diet – our fondness for fat and sugar. Most of us are far too fond of these for our own good. This was not a problem when our only sources of food had limited amounts of fats and sugars, but today we can greatly modify our food and over-process it to an extent that it poses a risk to human well being. Nor do I believe that supplementation of these over-processed foods by adding back in synthetic forms of the extracted nutrients is at all wise. There is evidence that such practices are doubly inimical to human health – not only has the over processing removed essential nutrients, the addition of synthetic forms of these poses chronic risk through the loading of the body with antichiral synthetics (manufactured forms of nutritional or medical compounds which have the correct gross chemistry, but which have the wrong stereoisometry for appropriate biochemical action).

Determining the health value of flavonoids

There are six main ways by which the effects of dietary flavonoids on human health may be evaluated: direct measurement of oxidative stress levels, epidemiological studies, repeated measures tests, laboratory (in vitro or in glass) biochemical or cytological studies, randomised double blind trials, and animal testing.

We can measure the site and extent of oxidative stress in human subjects by urine analysis. The beneficial effects of antioxidants can be assessed by measuring the decrease in oxidative stress levels following administration of dietary supplements. This is being researched at the present time and results are still to be evaluated, but initial results appear extremely promising.

Epidemiological studies can be divided into two types: observational and experimental. Observational studies compare the incidence of disease and longevity in flavonoid-rich populations, such as in the Mediterranean countries, with flavonoid-poor countries, such as the United Kingdom and the United States. The results indicate that a flavonoid-rich diet does, indeed, lead to increased longevity and better health, but other factors, such as genetic factors, may be involved. It is essential to maintain a wide range of different flavonoids from a variety of sources if you rely on natural dietary sources alone.

Experimental epidemiological studies rely on repeated measures, which are a scientific kind of “before and after” studies. An example of such studies is the Spanish women smokers study completed last year. Little benefit was recorded in lowering the incidence or outcome of lung cancer from a diet rich in flavonoids, but this is what may be expected in such a rampant form of cancer as lung cancer. Other studies have indicated that flavonoid supplements have very great benefits in both preventing diseases and in mitigating their effects.

Laboratory studies have shown that plant-derived antioxidants have great antioxidant activity. Platelet aggregation, thrombosis formation and plaque deposition are all reduced, thus explaining the epidemiological observations of reduced incidence of strokes and heart disease. The effects of flavonoids on cancer formation and propagation are also becoming understood. Again, the evidence is accumulating that flavonoids can help prevent certain cancers forming, growing and undergoing metastasis.

However, randomised double blind clinical trials of chronic effects of flavonoids are not as common, mainly because of expense and experimental difficulties. If you are studying the rate and age of onset chronic degenerative diseases it is scarcely practical to undertake clinical trials of twenty or thirty year duration. For similar reasons, “longitudinal” (life long) animal trials are rare. They are very expensive and are liable to be affected or destroyed by factors beyond control. The longer the duration of the experiment, the more likely these destructive events are to occur. So chronic experimentation, whether it is by the double blind methodology or fully controlled animal trials, tends to be rare. There have been some, however. Trials on vinegar flies in the early 1970s showed greatly increased longevity, and recent trials on mice have shown greatly reduced incidence of spontaneous old-age cancers, healthier and thicker coats, better cognitive skills, and increased longevity (Duncan, 1998).

Short-term studies of flavonoids are more popular amongst researchers. Recent studies are given in the references to this article.

Other benefits of flavonoids

Besides combating free radicals, flavonoids have been shown to have other beneficial effects including: adhesion receptor expression, slowing down or preventing bacterial replication (one of their main functions in living plants), slowing down viral replication, inhibiting proteolytic enzyme action, oestrogenic effects and carbohydrate induced AGE, (advanced glycosylation end products, where glucose and its polymers bond on to protein and cause the proteinacous materials of the body to become mucoid or amyloid material that “gums up the works”. An example of this is ageing of skin where collagen thickens and becomes less flexible because of glycosylation, and less flexible because of the cross linking due again to glycosylation. This, coupled with the loss of subdermal fat due to free radical damage and glycosylation, causes the appearance of old skin).

Conclusion

Free radicals are implicated as a major cause of many disease states in the human body, particularly chronic inflammatory and degenerative diseases such as arthritis, heart disease and cancer. There is a great deal of evidence suggesting that positive health benefits can be achieved by the adoption of a healthier lifestyle, a healthier diet richer in flavonoids and taking dietary supplements if the normal diet is deficient in flavonoids. The incidence of oxidative cell damage and general degenerative diseases is lowered by dietary flavonoids. There is also excellent evidence that the onset of these conditions can be delayed or even prevented by diets rich in flavonoids.

References

Ahmad N et al. 1998. Skin cancer chemopreventive effects of a flavonoid antioxidant silymarin are mediated via impairment of receptor tyrosine kinase. Biochem.& Biophys. Res. Comms. 247:294-301.
Ames B N et al. 1993. Oxidants, antioxidants, and the degenerative diseases of ageing. Proc. Natl. Acad. Sci. USA 90:7915-7922.
Bland J S. 1995. Oxidants and antioxidants in clinical medicine: past, present and future potential. J. Nutr. & Env. Med. 5:255-280.
Cheesman, K H and Slatter, T F. 1993. An Introduction to Free Radical Biochemistry. British Medical Bulletin 49:481-493.
Cheong H et al. 1998. Studies of structural activity relationships of flavonoids for the anti-allergic actions. Arch. Pharm. Res. 21:478-480.
Chevellier, A. The Encyclopaedia of Medicinal Plants. Dorking Kindersley. 1995.
Colgan, M. The New Nutrition. Medicine for the Millennium. C I Publications, San Diego. 1994.
Cross C E et al. 1987. Oxygen radicals and disease – Proceedings of the Davis Conference. Ann. Int. Med. 107:526-545.
Diplock A T. 1994. Antioxidants and disease prevention. Molec. Aspect. Med. 15:293-376.
Duncan, K W. (ed.) Fighting Free Radicals: the Enzogenol Story. (NZ & Australian Edition). The Pacific Scientific Press, Christchurch and Auckland, New Zealand. 1998.
Garrett, J T and M Garrett. Medicine of the Cherokee. Bear and Company, Santa Fe. 1996.
Gey K F. 1993. Prospects for the prevention of free radical disease, regarding cancer and cardiovascular disease. Brit. Med. Bull. 49(3):679-699.
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Rice-Evans C A et al. 1996. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Rad. Biol. & Med. 20(7).
Scrhramm D D, & German J B. 1998. Potential effects of flavonoids on the etiology of vascular disease. J. Nutr. Biochem. 9(10):560-566.
Sohn S J et al. 1998. Antigenotoxicity of galangin against n-methyl-n-nitrosourea. Mutat. Res. 402:231-236.
Soto C P et al. 1998. Prevention of alloxin-induced diabetes mellitus in the rat by silymarin. Comp. Biochem. Physiol. C: Comp. Pharm. & Tox. 119:125-129.
Takahashi T et al. 1999. Procyanidin oligomers selectively and intensively promote proliferation of mouse hair epithelial cells in vitro and activate hair follicle cells in vivo. J. Invest. Dermat. 112:310-316.
Whistler, W A. Polynesian Herbal Medicine. National London Tropical Botanical Garden, Hawaii. 1991.
Wyatt, J. 1994. The Roots of North American Medicine. Indian Life Magazine 15:3.
Xu et al. 1998. Effect of dietary catechin and vitamin E on aortic fatty streak accumulation in hypercholesterolemic hamsters. Atherosclerosis 137: 29-36.
You K M et al. 1999. Inhibition of cyclooxygenase/lipoxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from medicinal plants. Arch. Pham. Res. 22:18-24.
Zi X L et al. 1998. A flavonoid antioxidant, silymarin, inhibits activation of ERBBI signaling and induces cyclin-dependent kinase inhibitors, G1 arrest, and anticarcinogenic effects in human prostate carcinoma DU145 cells. Cancer Res. 58:1920-1929.

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December 3, 2007 Posted by | Antioxidants | | Leave a comment